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New applications of clioquinol in the treatment of inflammation disease by directly targeting arginine 335 of NLRP3

Peipei Chen Yunshu Wang Huaiping Tang Chao Zhou Zhuo Liu Shenghan Gao Tingting Wang Yun Xu Sen-Lin Ji

药物分析学报（英文）2025，Vol.15Issue(1)：151-171,21.

药物分析学报（英文）2025，Vol.15Issue(1)：151-171,21.DOI:10.1016/j.jpha.2024.101069

New applications of clioquinol in the treatment of inflammation disease by directly targeting arginine 335 of NLRP3

Peipei Chen ¹Yunshu Wang ¹Huaiping Tang ¹Chao Zhou ¹Zhuo Liu ¹Shenghan Gao ¹Tingting Wang ²Yun Xu ¹Sen-Lin Ji¹

作者信息

1. Department of Neurology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China||State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases,Nanjing University,Nanjing,210093,China||Jiangsu Key Laboratory for Molecular Medicine,Medical School of Nanjing University,Nanjing 210008,China||Nanjing Neurology Clinical Medical Center,Nanjing,210000,China
2. State Key Laboratory of Pharmaceutical Biotechnology,Chemistry and Biomedicine Innovation Center(ChemBIC),Jiangsu Key Laboratory of Molecular Medicine,Division of Immunology,Medical School,Nanjing University,Nanjing,210008,China
折叠

摘要

关键词

Clioquinol/NLRP3 inflammasome/NACHT domain/Sepsis/Peritonitis/Colitis

Key words

Clioquinol/NLRP3 inflammasome/NACHT domain/Sepsis/Peritonitis/Colitis

引用本文复制引用

Peipei Chen,Yunshu Wang,Huaiping Tang,Chao Zhou,Zhuo Liu,Shenghan Gao,Tingting Wang,Yun Xu,Sen-Lin Ji..New applications of clioquinol in the treatment of inflammation disease by directly targeting arginine 335 of NLRP3[J].药物分析学报（英文）,2025,15(1):151-171,21.

基金项目

This research was supported by the National Natural Science Foundation of China(Grant Nos.:82101417,81920108017,and 82130036),the STI2030-Major Projects(Project No.:2022ZD0211800),Jiangsu Province Key Medical Discipline(Grant No.:ZDXK202216),the Key Research and Development Program of Jiangsu Province of China(Program No.:BE2020620),and Nanjing Medical Science and technology development Foundation,China(Grant No.:YKK20061).We would like to thank Editchecks(https://editchecks.com.cn/)for providing linguistic assistance during the preparation of this manuscript. （Grant Nos.:82101417,81920108017,and 82130036）

药物分析学报（英文）

ISSN：2095-1779

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