医学新知2025，Vol.35Issue(4)：376-385,10.DOI:10.12173/j.issn.1004-5511.202501139
饮食因素对肠易激综合征的影响:两样本孟德尔随机化研究
Analysis of the effect of dietary factors on irritable bowel syndrome by Mendelian randomized method
摘要
Abstract
Objective To explore the causal relationship between dietary factors and the risk of developing irritable bowel syndrome(IBS)through Mendelian randomization analysis.Methods In the study,dietary factor-related characteristics from published Genome-Wide Association Study(GWAS)were selected and extracted as instrumental variables,and GWAS data on IBS were obtained from FinnGen Database.A two-sample Mendelian randomization analysis was primarily performed using the inverse variance weighted(IVW)method,and the test of heterogeneity,the test of pleiotropy,and sensitivity analyses were performed to guarantee the stability and reliability of the results.Results The results of IVW method showed that an increase in the average weekly beer and cider intake might significantly increase the risk of developing IBS[OR=2.043,95％CI(1.126,3.708),P=0.019].Conversely,an increase in coffee consumption[OR=0.671,95％CI(0.473,0.952),P=0.025]and dried fruits intake[OR=0.452,95％CI(0.293,0.697),P＜0.001]appeared to correlate with a decreased risk of developing IBS,where the results for dried fruit intake showed a similar pattern of results in the weighted median method analysis[OR=0.427,95％CI(0.231,0.787),P=0.006].Conclusion The findings suggest a causal relationship between the average weekly intake of beer and cider,coffee,dried fruit and the risk of developing IBS.These findings emphasize the importance of making sound dietary choices in the prevention of IBS.关键词
饮食因素/肠易激综合征/孟德尔随机化/全基因组关联研究Key words
Dietary factors/Irritable bowel syndrome/Mendelian randomization/Genome-wide association study分类
医药卫生引用本文复制引用
张惠芳,汪彦平,王慧敏,马小彤,郭庆红,陈兆峰..饮食因素对肠易激综合征的影响:两样本孟德尔随机化研究[J].医学新知,2025,35(4):376-385,10.基金项目
甘肃省科技计划联合科研基金重大项目(23JRRA1487) （23JRRA1487）
