烟台大学学报（自然科学与工程版）2025，Vol.38Issue(2)：224-232,9.DOI:10.13951/j.cnki.37-1213/n.240309
多奈哌齐纳米混悬复合凝胶剂的制备及评价
Preparation and Evaluation of Donepezil Nanosuspension Composite Gel
摘要
Abstract
To achieve sustained-release of donepezil(DPZ),this study prepared donepezil nanosuspension(DPZ-NS)using wet medium grinding,and then mixed it with different polymers/poloxamer composite thermosensitive gels to obtain donepezil nanosuspension composite gels(DPZ-NS-gel-PM).Gelation temperature,viscosity,in vitro release,and in vitro degradation were used as evaluation indicators to screen the types(hydroxypropyltrimethyl ammonium chloride chitosan,sodium alginate,and hydroxypropyl methylcellulose(HPMC))and contents of poly-mers.The optimized formulation was then evaluated both in vitro and in vivo.The results showed that the DPZ-NS-gel-HPMC with 0.5%HPMC had the best sustained-release effect,possibly due to the strong hydrogen bonding in-teraction between HPMC and the gel matrix.Its gelation temperature was(32.2±0.2)℃,and the viscosity was(163.2±1.3)mPa·s.There was a linear relationship between drug release and gel degradation.The formulation achieved sustained release of the drug for 20 days in rats and exhibited good tissue safety.This formulation has good long-acting sustained-release properties and promising application prospects.关键词
多奈哌齐/纳米混悬剂/凝胶/羟丙基甲基纤维素/缓释Key words
donepezil/nanosuspension/gel/hydroxypropyl methylcellulose/sustained-release分类
医药卫生引用本文复制引用
崔楠,王琳琳,杨芸,王爱萍..多奈哌齐纳米混悬复合凝胶剂的制备及评价[J].烟台大学学报（自然科学与工程版）,2025,38(2):224-232,9.基金项目
山东省自然科学基金资助项目(ZR2022MH260). （ZR2022MH260）
