Discovery of E0199:A novel compound targeting both peripheral Nav and Kv7 channels to alleviate neuropathic pain
Boxuan Zhang Yawen Cao Xu Chai Jiahao Wang Yang Zhang Xiangyu Wang Qingzhong Jia Xiaoxing Shi Xingang Liu Yan Liu Xuedong Li Qi Wang Dongyang Huang Weidong Zhao Junru Cui
Discovery of E0199:A novel compound targeting both peripheral Nav and Kv7 channels to alleviate neuropathic pain
Discovery of E0199:A novel compound targeting both peripheral Nav and Kv7 channels to alleviate neuropathic pain
摘要
关键词
Neuropathic pain/Nay channel/Kv7 channel/Dorsal root gangliaKey words
Neuropathic pain/Nay channel/Kv7 channel/Dorsal root ganglia引用本文复制引用
Boxuan Zhang,Yawen Cao,Xu Chai,Jiahao Wang,Yang Zhang,Xiangyu Wang,Qingzhong Jia,Xiaoxing Shi,Xingang Liu,Yan Liu,Xuedong Li,Qi Wang,Dongyang Huang,Weidong Zhao,Junru Cui..Discovery of E0199:A novel compound targeting both peripheral Nav and Kv7 channels to alleviate neuropathic pain[J].药物分析学报（英文）,2025,15(1):244-261,18.基金项目
This study was funded by the Key Project from the Hebei Pro-vincial Department of Science and Technology,China(Grant No.:21372601D),the Foundation Postdoctoral Mobile Station of Basic Medical Sciences,Hebei Medica l University,China(Grant No.:20123120019),the Natural Science Foundation of Hebei Province,China(Grant No.:H2021206352),the Science and Technology Research Project of Colleges and Universities in Hebei Province,China(Grant No.:QN2023197),Hebei Medical University,Science and Technology,China(Grant No.:CYQD2023014),Hebei Provincial Department of Human Resources and Social Security,China(Grant No.:B2023003034),and the Consultative Foundation from Hebei Province,China(Grant No.:2020TXZH01).We would like to thank Professor Zhaobing Gao from Chinese Academy of Sciences,China for providing us plasmid ofNay1.6,as well as Professor Kewei Wang and Dr.Yani Liu from Qingdao University,China,who provided us stable cells expressing Nay1.4 channel. （Grant No.:21372601D）
