中风与神经疾病杂志2025，Vol.42Issue(4)：335-340,6.DOI:10.19845/j.cnki.zfysjjbzz.2025.0066
非传统血脂指标与脑小血管病患者认知功能的相关性研究
Association between non-traditional blood lipid parameters and cognitive function in patients with cerebral small vessel disease
摘要
Abstract
Objective To explore the association between cognitive function and non-traditional blood lipid param-eters in patients with cerebral small vessel disease(CSVD).Methods A prospective study was conducted among 376 CSVD patients who were treated in Dongfang Hospital,Beijing University of Chinese Medicine,from July 2017 to August 2022.Blood samples were collected from all subjects in the morning after 12 hours of fasting to measure blood lipid parameters,and then non-traditional blood lipid parameters were calculated.According to the Montreal Cognitive Assessment Scale,the patients were divided into cognitive impairment CSVD group and non-cognitive impairment CSVD group.A multivariate logistic regression analysis was used to investigate the association between non-traditional blood lipid parameters and cognitive function in CSVD patients,and the receiver operating characteristic(ROC)curve was used to assess their predictive value.Results A total of 376 CSVD patients were enrolled,among whom there were 250 patients with cognitive impairment and 126 patients without cognitive impairment.The multivariate logistic regres-sion analysis showed that TC/HDL-C(OR=1.454,95%CI 1.147-1.843,P=0.002)and LDL-C/HDL-C ratio(OR=1.457,95%CI 1.109-1.915,P=0.023)were independently associated with cognitive impairment in CSVD patients.The ROC curve analysis showed that TC/HDL-C ratio had an area under the ROC curve(AUC)of 0.606(95%CI 0.547-0.665)in predicting cognitive impairment in CSVD patients,with a sensitivity of 0.560 and a specificity of 0.659;LDL-C/HDL-C ratio had an AUC 0.617(95%CI 0.558-0.676)in predicting cognitive impairment,with a sensitivity of 0.552 and a specificity of 0.762;TC/HDL-C ratio combined with LDL-C/HDL-C ratio had an AUC of 0.776(95%CI 0.726-0.825)in predicting cognitive impairment,with a sensitivity of 0.772 and a specificity of 0.667.Conclusion Increases in TC/HDL-C ratio and LDL-C/HDL-C ratio are risk factors for cognitive impairment in CSVD pa-tients and thus have a certain predictive value for cog-nitive impairment in CSVD patients,and the combina-tion of these two ratios has a higher predictive value.关键词
脑小血管病/认知障碍/非传统血脂指标Key words
Cerebral small vessel disease/Cognitive impairment/Non-traditional blood lipid parameters分类
医药卫生引用本文复制引用
李施新,段佳钰,靳会会,王业飞,秦璎琳,宋佳乐,李晓杉,金香兰..非传统血脂指标与脑小血管病患者认知功能的相关性研究[J].中风与神经疾病杂志,2025,42(4):335-340,6.基金项目
中华中医药学会研究与评价专项课题(CACMRE2021-A-06) （CACMRE2021-A-06）
北京中医药大学基本科研业务费重点攻关项目(2020-JYB-ZDGG-124) （2020-JYB-ZDGG-124）
