中风与神经疾病杂志2025，Vol.42Issue(4)：341-351,11.DOI:10.19845/j.cnki.zfysjjbzz.2025.0067
91例MOGAD患者的临床特点及复发风险与长期预后评估
Clinical features,recurrence risk,and long-term prognosis of anti-myelin oligodendrocyte glycoprotein-IgG asso-ciated disorders:An analysis of 91 cases
摘要
Abstract
Objective To investigate the clinical features and treatment of anti-myelin oligodendrocyte glycoprotein-IgG associated disorders(MOGAD)and the risk factors for recurrence and poor long-term prognosis.Methods A total of 91 patients who were diagnosed with MOGAD in The First Affiliated Hospital of Zhengzhou University from January 2018 to March 2023 were enrolled,and their clinical features and auxiliary examinations were analyzed,as well as the risk factors for recurrence and long-term prognosis.Results Among the 91 patients,69 experienced the first attack of MOGAD,and there were 39 female patients and 47 children(aged<18 years).The proportion of patients with acute disseminated encephalomy-elitis among children was significantly higher than that among adults(42.6%vs 18.2%,P=0.012),while the proportion of patients with transverse myelitis among adults was significantly higher than that among children(29.5%vs 2.1%,P<0.001).The proportion of patients receiving hormones combined with immunoglobulins during hospitalization among chil-dren was significantly higher than that among adults(36.2%vs 11.4%,P=0.006),and the children had a significantly bet-ter Expanded Disability Status Scale(EDSS)score than the adults at discharge[1(0,1)vs 2(0,4.75),P=0.007].Visual im-pairment was an independent risk factor for increased recurrence risk(OR=4.215,95%CI 1.236-14.377,P=0.022).A higher EDSS score at discharge(OR=5.05,95%CI 1.27-20.07,P=0.021)and a higher number of attacks(OR=9.235,95%CI 1.352-63.10,P=0.023)were independent factors for poor long-term prognosis,while a steroid maintenance time of>5 weeks at initial diagnosis(OR=0.001,95%CI 0.00-0.33,P=0.001)was an independent factor for improving long-term prognosis.Conclusion For patients newly diagnosed with MOGAD,especially those with a high EDSS score at dis-charge and features indicating a high risk of recurrence(such as visual impairment),it is recommended that they receive an appropriate course of steroid maintenance treatment after acute-stage treatment.关键词
抗髓鞘少突胶质细胞糖蛋白免疫球蛋白G抗体相关疾病/临床特点/脑脊液/复发/预后Key words
Anti-myelin oligodendrocyte glycoprotein-IgG associated disorders/Clinical features/Cerebrospinal fluid/Recurrence/Prognosis分类
医药卫生引用本文复制引用
孙文琳,谢银银,韩奥娅,周鑫茹,谢祎,徐洪亮,谢南昌..91例MOGAD患者的临床特点及复发风险与长期预后评估[J].中风与神经疾病杂志,2025,42(4):341-351,11.基金项目
河南省中青年健康科技创新杰出青年人才项目(YXKC2022037) （YXKC2022037）
