中风与神经疾病杂志2025，Vol.42Issue(4)：352-356,5.DOI:10.19845/j.cnki.zfysjjbzz.2025.0068
老年急性缺血性脑卒中患者PIV、non-HDL-C、IL谱特征与神经功能损伤严重程度的相关性分析
Characteristics of pan-immune-inflammation value,non-high-density lipoprotein cholesterol,and interleukin spectrum and their correlation with the severity of neurological function impairment in elderly patients with acute ischemic stroke
摘要
Abstract
Objective To investigate the characteristics of pan-immune-inflammation value(PIV),non-high-density li-poprotein cholesterol(non-HDL-C),and interleukin(IL)spectrum and their correlation with the severity of neurological function impairment in elderly patients with acute ischemic stroke.Methods A retrospective analysis was performed for 158 elderly pa-tients with acute ischemic stroke who were hospitalized in our hospital from October 2019 to October 2024,and according to the se-verity of neurological function impairment,they were divided into non-severe neurological function impairment group with 112 pa-tients and severe neurological function impairment group with 46 patients.The two groups were compared in terms of general clini-cal data,PIV,non-HDL-C,and ILs.A logistic regression analysis was used to investigate the risk factors for severe neurological function impairment in elderly patients with acute ischemic stroke,and the receiver operating characteristic(ROC)curve was used to evaluate the predictive value of each risk factor.Results Compared with the non-severe neurological function impairment group,the severe neurological function impairment group had a significantly lower level of HDL-C and significantly higher levels of non-HDL-C,PIV,IL-1β,IL-6,and IL-8(P<0.05).The multivariate logistic regression analysis showed that HDL-C,non-HDL-C,PIV,IL-1β,IL-6,and IL-8 were influencing factors for severe neurological function impairment in elderly patients with acute ischemic stroke(P<0.05).The ROC curve analysis showed that the combination of HDL-C,non-HDL-C,PIV,IL-1β,IL-6,and IL-8 had a significantly higher efficiency than each indicator alone in predicting severe neurological function impairment in elderly patients with acute ischemic stroke(Z=4.234,4.411,3.897,4.240,4.001,4.420,all P<0.001).Conclusion El-derly patients with acute ischemic stroke who have relatively high levels of PIV,non-HDL-C,and pro-inflammatory ILs tend to have severe neurological function impairment.关键词
老年/缺血性脑卒中/泛免疫炎症值/非高密度脂蛋白胆固醇/白细胞介素Key words
Elderly/Ischemic stroke/Pan-immune inflammation value/Non-high-density lipoprotein cho-lesterol/Interleukin分类
医药卫生引用本文复制引用
张海涛,葛仁美,刘小江..老年急性缺血性脑卒中患者PIV、non-HDL-C、IL谱特征与神经功能损伤严重程度的相关性分析[J].中风与神经疾病杂志,2025,42(4):352-356,5.基金项目
江苏省卫生健康委员会医学科研项目(ZQ2024005) （ZQ2024005）
