医学新知2025，Vol.35Issue(4)：452-460,9.DOI:10.12173/j.issn.1004-5511.202502012
前列腺癌内分泌治疗抵抗机制的研究进展
Research progress on mechanisms of endocrine therapy resistance in prostate cancer
摘要
Abstract
Prostate cancer(PCa)is one of the most prevalent malignancies among men worldwide and a leading cause of cancer-related deaths.As an androgen-dependent tumor of the male reproductive system,PCa initially responds well to androgen deprivation therapy(ADT)and second-generation androgen receptor(AR)antagonists(enzalutamide and apalutamide),which significantly extend progression-free survival.However,Most patients would developed into castration-resistant prostate cancer(CRPC),resulting in the resistant to ADT.The mechanisms driving resistance to novel endocrine therapies exhibit biological complexity,including abnormalities in the AR signaling axis,defects in DNA damage repair,alterations in the tumor microenvironment,and metabolic reprogramming.In recent years,important advances have been made in targeted therapeutic strategies.For instance,PARP inhibitors(olaparib)have demonstrated remarkable efficacy in patients with defects in DNA damage repair,PROTAC technology has shown potential in reversing castration resistance by degrading AR and its variants,thereby countering aberrant activation of the AR signaling pathway.This review systematically elucidates the major resistance mechanisms of CRPC,explores the latest advances in targeted and immunotherapy for CRPC,and envisions the potential of multidisciplinary,multi-target combination therapies to reverse castration resistance in PCa,providing novel therapeutic strategies and targets for CRPC.关键词
前列腺癌/雄激素受体/雄激素剥夺治疗/去势抵抗/耐药机制Key words
Prostate cancer/Androgen receptor/Androgen deprivation therapy/Castration resistance/Drug resistance mechanism分类
医药卫生引用本文复制引用
戚子昊,曾宪涛,王雷杰,吴林杰,白小杰,樊九铭,王天堃,韩雨桐,于营,郭中强..前列腺癌内分泌治疗抵抗机制的研究进展[J].医学新知,2025,35(4):452-460,9.基金项目
国家自然科学基金面上项目(8217113347) （8217113347）
国家自然科学基金青年科学基金项目(82403905) （82403905）
