中风与神经疾病杂志2025，Vol.42Issue(4)：357-360,4.DOI:10.19845/j.cnki.zfysjjbzz.2025.0069
神经梅毒合并HIV感染相关的急性缺血性卒中1例报告并文献复习
Acute ischemic stroke associated with neurosyphilis comorbid with HIV infection:A case report and literature review
摘要
Abstract
This article reports a male patient,aged 31 years,who were admitted due to sudden-onset speech and language impairment and limb weakness at the right side for more than 7 hours and achieved successful revascularization after endovascular treatment.Etiological screening revealed positive treponema pallidum particle agglutination(1∶1 280)and positive HIV antibodies in serum,as well as an increase in white blood cell count and positive TPPA(1∶640)in cere-brospinal fluid(CSF).High-resolution magnetic resonance imaging of the vessel wall showed inflammatory changes in the vessel wall of the M1 segment of the left middle cerebral artery.After multidisciplinary consultation,the patient was diag-nosed with acute ischemic stroke secondary to cerebral arteritis caused by neurosyphilis and HIV infection and was given antiplatelet therapy,benzathine penicillin for syphilis,and antiviral therapy.After 6 months of follow-up,the patient had a modified Rankin Scale score of 0 and achieved clearance of syphilis-related indicators in serum and CSF,and CT angiog-raphy confirmed revascularization without new-onset stenosis.The literature review shows that acute ischemic stroke is a common manifestation of co-infection with HIV and neurosyphilis in young individuals,and early syphilis detection in se-rum and CSF,HIV screening,and timely combination therapy are of great significance for improving prognosis.关键词
神经梅毒/缺血性卒中/动脉炎/大脑中动脉闭塞/高分辨率磁共振成像Key words
Neurosyphilis/Ischemic stroke/Arteritis/Middle cerebral artery occlusion/High-resolution magnetic resonance imaging分类
医药卫生引用本文复制引用
罗钰鼎,陈传立,熊海,段川西,李璐,陈钊,郑波,王建..神经梅毒合并HIV感染相关的急性缺血性卒中1例报告并文献复习[J].中风与神经疾病杂志,2025,42(4):357-360,4.基金项目
四川省自然科学基金面上项目(2025ZNSFSC0618) （2025ZNSFSC0618）
四川省卫生健康委员会临床研究专项基金(23LCYJ034) （23LCYJ034）
四川省医学科技创新研究会专项基金(YCH-KY-YCZD2024-037) （YCH-KY-YCZD2024-037）
