医学新知2025，Vol.35Issue(4)：461-468,8.DOI:10.12173/j.issn.1004-5511.202411243
儿童大环内酯类耐药的重症肺炎支原体肺炎早期识别与治疗
Early identification and treatment of macrolide-resistant severe Mycoplasmal pneumoniae pneumonia in children
摘要
Abstract
Mycoplasmal pneumoniae pneumonia(MPP)is a common respiratory disease in children.The incidence of severe MPP(SMPP)has increased and the situation is critical due to a variety of factors such as declining herd immunity,macrolide antibiotic resistance,delayed diagnosis and treatment,and mixed infection.Most children with SMPP have severe clinical symptoms and a long course of disease.SMPP is prone to serious complications such as lung consolidation,atelectasis,plastic bronchitis,necrotizing pneumonia,and extrapulmonary manifestations,leaving behind chronic lung diseases such as bronchiectasis and bronchiolitis obliterans,which affect the quality of children's life.Children who are likely to develop SMPP should be given high attention.Early identification of SMPP with macrolide-resistant can be achieved by clinical manifestations,relevant laboratory tests,lung imaging,and bronchoscopic changes,and individualized treatment plan can be adjusted in time.Early diagnosis and effective treatment can alleviate the pain of children,shorten the course of disease,and reduce the incidence of severe diseases.This article reviews the early identification and treatment of severe macrolide-resistant MPP in children.关键词
肺炎支原体/大环内酯类抗生素/耐药/重症肺炎/早期识别/治疗Key words
Mycoplasma pneumoniae/Macrolide antibiotics/Drug resistance/Severe pneumonia/Early identification/Treatment分类
医药卫生引用本文复制引用
于曼,叶乐平..儿童大环内酯类耐药的重症肺炎支原体肺炎早期识别与治疗[J].医学新知,2025,35(4):461-468,8.基金项目
国家自然科学基金面上项目(82371708) （82371708）
北京大学第一医院跨学科交叉研究专项(2023IR03) （2023IR03）
