中风与神经疾病杂志2025，Vol.42Issue(4)：361-364,4.DOI:10.19845/j.cnki.zfysjjbzz.2025.0070
狒狒巴拉姆希阿米巴脑炎1例报告并文献复习
Balamuthia mandrillaris amoebic encephalitis:A case report and literature review
陈余榕 1张奇山 1谢志文 1刘世杰 1罗莎林1
作者信息
- 1. 南华大学附属郴州医院,郴州市第一人民医院神经内科,湖南 郴州 423000
- 折叠
摘要
Abstract
Infection of the human central nervous system by Balamuthia mandrillaris is very rare and is mostly observed in people engaged in agriculture-related occupations,with a high fatality rate.This article reports a case of Balamuthia mandrillaris amoebic encephalitis in southern Hunan,China,which was finally confirmed by metagenomic next-generation sequencing of cerebrospinal fluid.The patient gave up treatment and was discharged from the hospital without achieving remission after antiviral,anti-fungal,and anti-parasitic therapies,cranial pressure reduction,and symptomatic supportive treatment,and the patient died at 5 months after confirmed diagnosis.This article reviews related literature to improve the understanding of this disease among clinicians,and it is necessary to consider the possibility of this disease in case of encephalitis of unknown etiology.Early diagnosis and timely comprehensive anti-infective therapy should be performed to improve the success rate of treatment.关键词
巴拉姆希阿米巴/肉芽肿性阿米巴脑炎/感染/宏基因二代测序Key words
Balamuthia mandrillaris/Granulomatous amoebic encephalitis/Infection/Metagenomic next-generation sequencing分类
医药卫生引用本文复制引用
陈余榕,张奇山,谢志文,刘世杰,罗莎林..狒狒巴拉姆希阿米巴脑炎1例报告并文献复习[J].中风与神经疾病杂志,2025,42(4):361-364,4.
