医学新知2025，Vol.35Issue(4)：469-475,7.DOI:10.12173/j.issn.1004-5511.202409141
肝纤维化中T淋巴细胞对肝星状细胞活化的影响
Effect of T lymphocyte on hepatic stellate cell activation in liver fibrosis
摘要
Abstract
Liver fibrosis is a repair reaction of the whole body after liver injury caused by many causes(such as viral hepatitis and metabolic dysfunction-associated steatotic liver disease).It is mainly manifested as excessive proliferation and deposition of extracellular matrix in liver tissue,which leads to abnormal changes in liver tissue structure,cirrhosis and liver failure,and affects the normal physiological function of liver.Activated hepatic stellate cells(HSC)are generally considered to be the main cell type that forms liver fibrosis.During liver fibrosis,immune cells play an important role in regulating the activation of HSC,such as interleukin 17(IL-17),IL-10 and transforming growth factor β,which are secreted by immune cells in the liver,including helper T cells 17,Th1/Th2 cells,and regulatory T cells.This paper mainly introduces the regulation of T lymphocytes on HSC activation and its impact in fibrosis to expand potential therapeutic approaches to modulate liver fibrosis.关键词
T淋巴细胞/肝纤维化/肝星状细胞/免疫微环境Key words
T lymphocyte/Liver fibrosis/Hepatic stellate cells/Immune microenvironment分类
医药卫生引用本文复制引用
龚晓倩,魏业煌,王蓉蓉,刘旭东..肝纤维化中T淋巴细胞对肝星状细胞活化的影响[J].医学新知,2025,35(4):469-475,7.基金项目
国家自然科学基金地区科学基金项目(82160837) （82160837）
广西中医药大学岐黄工程高层次人才团队培养项目(桂中医大人(2021)10号) （桂中医大人(2021）
全国中医临床优秀人才研修项目(国中医药人教函[2022]1号) （国中医药人教函[2022]1号）
