中风与神经疾病杂志2025，Vol.42Issue(4)：365-369,5.DOI:10.19845/j.cnki.zfysjjbzz.2025.0071
褪黑素调控昼夜节律对认知功能的影响及机制
The impact and mechanism of melatonin on cognitive function by regulating circadian rhythms
摘要
Abstract
Circadian rhythm is an essential biological process that regulates the sleep-wake cycle,hormone secre-tion,and metabolism,and the stability of circadian rhythm is crucial for maintaining normal cognitive function.Melatonin(MT),a key hormone secreted by the pineal gland,is involved in the regulation of circadian rhythm and thus has a signifi-cant impact on cognitive function.This article systematically reviews the multiple mechanisms by which MT regulates cog-nitive function through circadian rhythm,including improving sleep quality,promoting the clearance of metabolic waste by the glymphatic system,exerting antioxidant and anti-inflammatory effects,and regulating neuronal activity and the im-provement of synaptic plasticity.In addition,this article also discusses the association between circadian rhythm disorders and neurodegenerative diseases.Future studies are needed in the future to further clarify the neuroprotective mechanisms of MT,in order to provide new insights for the prevention and treatment of cognitive impairment.关键词
褪黑素/昼夜节律/认知功能/胶质淋巴系统/水通道蛋白-4Key words
Melatonin/Circadian rhythm/Cognitive function/Glymphatic system/Aquaporin-4分类
临床医学引用本文复制引用
翁克威,王改青..褪黑素调控昼夜节律对认知功能的影响及机制[J].中风与神经疾病杂志,2025,42(4):365-369,5.基金项目
海南省重点研发项目(ZDYF2023SHFZ104) （ZDYF2023SHFZ104）
三亚市科技创新专项项目(2022KJCX24) （2022KJCX24）
三亚中心医院院级自然科学基金项目(SYZXYY202408) （SYZXYY202408）
