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Hemodynamic disturbance and mTORC1 activation:Unveiling the biomechanical pathogenesis of thoracic aortic aneurysms in Marfan syndrome

Ming-Yuan Liu Meili Wang Junjun Liu An-Qiang Sun Chang-Shun He Xin Conag Wei Kong Wei Li

药物分析学报（英文）2025，Vol.15Issue(2)：459-473,15.

药物分析学报（英文）2025，Vol.15Issue(2)：459-473,15.DOI:10.1016/j.jpha.2024.101120

Hemodynamic disturbance and mTORC1 activation:Unveiling the biomechanical pathogenesis of thoracic aortic aneurysms in Marfan syndrome

Ming-Yuan Liu ¹Meili Wang ²Junjun Liu ³An-Qiang Sun ⁴Chang-Shun He ⁵Xin Conag ⁶Wei Kong ⁶Wei Li⁷

作者信息

1. Department of Vascular Surgery,Beijing Friendship Hospital,Capital Medical University,Beijing Center of Vascular Surgery,Beijing 100050,China||Department of Vascular Surgery,Peking University People's Hospital,Beijing,100044,China
2. Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Capital Medical University,Beijing,100069,China
3. Department of Vascular Surgery,The Affiliated Hospital of Qingdao University,Qingdao,266000,Shandong,China
4. School of Biological Science and Medical Engineering,Beihang University,Beijing,100083,China
5. Department of Vascular Surgery,Peking University People's Hospital,Beijing,100044,China
6. Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Peking University,Beijing 100191,China||The Key Laboratory of Molecular Cardiovascular Science,Ministry of Education,Beijing 100191,China
7. Department of Vascular Surgery,Peking University People's Hospital,Beijing,100044,China||The Key Laboratory of Molecular Cardiovascular Science,Ministry of Education,Beijing 100191,China
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摘要

关键词

Thoracic aortic aneurysm(TAA)/mTORC1/Marfan syndrome/Biomechanicalpathogenesis/Wall shear stress(WSS)

Key words

Thoracic aortic aneurysm(TAA)/mTORC1/Marfan syndrome/Biomechanicalpathogenesis/Wall shear stress(WSS)

引用本文复制引用

Ming-Yuan Liu,Meili Wang,Junjun Liu,An-Qiang Sun,Chang-Shun He,Xin Conag,Wei Kong,Wei Li..Hemodynamic disturbance and mTORC1 activation:Unveiling the biomechanical pathogenesis of thoracic aortic aneurysms in Marfan syndrome[J].药物分析学报（英文）,2025,15(2):459-473,15.

基金项目

This work was supported by the National Natural Science Foun-dation of China(Grant Nos.:82000429 and 81470574),Young Elite Scientists Sponsorship Program by CAST,China(Program No.:YESS20230395/2023QNRC001),Beijing Nova Program,China(Pro-gram No.:20230484308),Youth Elite Program of Beijing Friendship Hospital,China(Program No.:YYQCJH2022-9),Young Elite Scientists Sponsorship Program by BAST,China(Program No.:BYESS2024045),Capital's Funds for Health Improvement and Research,China(Grant No.:CFH2022-4-20217),and Chinese Institutes for Medical Research,Beijing(CIMR)Organized Research Project,China(Project No.:CX23YQ07).We thank Prof.Yi Fu,Dr.Bing Yu,Dr.Ze Gong at the Laboratory of Vascular Remodeling,School of Basic Medical Sciences,Peking University for their tremendous help in the experiment. （Grant Nos.:82000429 and 81470574）

药物分析学报（英文）

ISSN：2095-1779

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