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Radiosynthesis and preclinical evaluation of[18F]AlF-labeled HBED-CC-FAPI derivatives for imaging of cancer-associated fibroblasts

Haiyan Hong Yan Zhang Jinping Qiao Wensheng Zhang Lin Zhu Jiehua Xu

药物分析学报（英文）2025，Vol.15Issue(2)：484-487,4.

药物分析学报（英文）2025，Vol.15Issue(2)：484-487,4.DOI:10.1016/j.jpha.2024.101107

Radiosynthesis and preclinical evaluation of[18F]AlF-labeled HBED-CC-FAPI derivatives for imaging of cancer-associated fibroblasts

Haiyan Hong ¹Yan Zhang ²Jinping Qiao ³Wensheng Zhang ⁴Lin Zhu ³Jiehua Xu⁵

作者信息

1. Department of Nuclear Medicine,Zhuhai People's Hospital(Zhuhai Clinical Medical College of Jinan University),Zhuhai,Guangdong,519000,China||Engineering Research Center of Natural Medicine,Ministry of Education,Beijing Normal University at Zhuhai,Zhuhai,Guangdong,519087,China
2. Department of Nuclear Medicine,Beijing Tsinghua Changgung Hospital(School of Clinical Medicine,Tsinghua University),Beijing,102218,China
3. Key Laboratory of Radiopharmaceuticals,Ministry of Education,Beijing Normal University,Beijing,100875,China
4. Engineering Research Center of Natural Medicine,Ministry of Education,Beijing Normal University at Zhuhai,Zhuhai,Guangdong,519087,China
5. Department of Nuclear Medicine,Zhuhai People's Hospital(Zhuhai Clinical Medical College of Jinan University),Zhuhai,Guangdong,519000,China
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摘要

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Haiyan Hong,Yan Zhang,Jinping Qiao,Wensheng Zhang,Lin Zhu,Jiehua Xu..Radiosynthesis and preclinical evaluation of[18F]AlF-labeled HBED-CC-FAPI derivatives for imaging of cancer-associated fibroblasts[J].药物分析学报（英文）,2025,15(2):484-487,4.

基金项目

This study was supported by the grants provided by Zhuhai People's Hospital,China(Grant No.:2021KYQD-03)and the Na-tional Natural Science Foundation of China(Grant No.:22176016).The authors thank Prof.Hank F.Kung(Department of Radiology,University of Pennsylvania,Philadelphia,PA,USA)for the assistance in study design and manuscript preparation,Prof.Zuoxiang He(Department of Nuclear Medicine,Beijing Tsinghua Changgung Hospital(School of Clinical Medicine,Tsinghua University),Beijing,China)for the assistance in providing[18F]fluoride,and Dr.Shisong Han(Department of Nuclear Medicine,Zhuhai People's Hospital(Zhuhai Clinical Medical College of Jinan University),Zhuhai,China)for the suggestions in study execution.We thank LetPub(www.letpub.com.cn)for its linguistic assistance during the preparation of this manuscript. （Grant No.:2021KYQD-03）

药物分析学报（英文）

ISSN：2095-1779

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