中国感染控制杂志2025，Vol.24Issue(4)：492-498,7.DOI:10.12138/j.issn.1671-9638.20256833
组织学绒毛膜羊膜炎与羊水胎粪污染对新生儿不良妊娠结局的关联性
Histological chorioamnionitis,meconium-stained amniotic fluid,and ad-verse pregnancy outcomes in neonates:a correlation analysis
摘要
Abstract
Objective To investigate the association of histological chorioamnionitis(HCA)and meconium-stained amniotic fluid(MSAF)with adverse pregnancy outcomes in neonates.Methods Neonates and their mothers who delivered from May 2021 to January 2024 in the department of neonatology in a hospital were selected as the re-search subjects.According to placenta pathological diagnosis,participants were divided into the HCA group and the non-HCA group.Clinical data,MSAF incidence,and adverse pregnancy outcomes among neonates with different MSAF levels were compared between two groups.The relationship between HCA and adverse pregnancy outcomes in neonates with different MSAF severity levels was analyzed using logistic regression analysis model,and the im-pact of the interaction between HCA and MSAF on adverse pregnancy outcomes in neonates was evaluated.Results A total of 300 neonates and their mothers were included in the analysis,with 113 in the HCA group and 187 in the non-HCA group.There was a statistical difference in the occurrence of MSAF with different severity between two groups of neonates(x2=25.39,P＜0.05).The incidence of HCA increased with the increased severity of MSAF.The incidences of neonatal pneumonia,intraventricular hemorrhage,early-onset septicemia and bronchopulmonary dysplasia were all statistically different under different MSAF levels(all P＜0.05).As MSAF severity increased,the risk of neonates developing the above-mentioned diseases also increased gradually.HCA was found to be inde-pendently associated with neonatal pneumonia,intraventricular hemorrhage,early-onset sepsis,and bronchopulmo-nary dysplasia under different MSAF levels.Interaction analysis revealed that when HCA and MSAF co-occurred,there was a remarkable increase in the risk of adverse pregnancy outcomes in neonates(OR=6.30;95％CI:2.53-10.20).Conclusion MSAF and HCA are both independent risk factors for adverse pregnancy outcomes in neo-nates,and the coexistence of MSAF and HCA significantly increases this risk.关键词
组织学绒毛膜羊膜炎/羊水胎粪污染/不良妊娠结局/相关性/新生儿Key words
histological chorioamnionitis/meconium-stained amniotic fluid/adverse pregnancy outcome/correla-tion/neonate分类
医药卫生引用本文复制引用
杨琨,邱雷,张丽丽..组织学绒毛膜羊膜炎与羊水胎粪污染对新生儿不良妊娠结局的关联性[J].中国感染控制杂志,2025,24(4):492-498,7.基金项目
巴音郭楞蒙古自治州科学技术研究计划(202128) （202128）
