中国临床医学2025，Vol.32Issue(2)：165-170,6.DOI:10.12025/j.issn.1008-6358.2025.20250032
基于倾向评分匹配分析内淋巴囊手术治疗梅尼埃病的效果
Effect analysis of endolymphatic sac surgery on Meniere's disease based on propensity score matching
摘要
Abstract
Objective To analyse the clinical efficiency of endolymphatic sac surgery(ESS)in the management of Meniere's disease(MD).Methods A retrospective analysis was conducted on 274 patients with MD who were hospitalized for treatment in Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University from January 2009 to August 2023.All patients received lifestyle management and drug treatment such as diuretics.For those whose conditions were not well controlled 3 to 6 months after the initial treatment,intratympanic glucocorticoid(ITG)or ESS treatment was carried out.Six months after the treatment,the classes of vertigo relief and hearing changes in the patients were evaluated.After adjusting the confounding factors through propensity score matching(PSM),the impact of ESS on the prognosis of MD patients was evaluated.Results Among 274 patients,194 and 80 patients underwent ITG and ESS,respectively.Eighty patients were enrolled into each group after PSM.Before and after PSM,the rate of patients reaching vertigo relief class A in ESS group was higher than that in the ITG group(P=0.004);there was no significant difference in hearing preservation between the two groups.Kaplan-Meier curve analysis showed that vertigo relief in the ESS group was better than that in the ITG group(P=0.029);there was no statistically significant difference in hearing preservation between the two groups.Conclusion When the initial treatment for patients with MD is ineffective,choosing ESS is more beneficial than ITG for controlling vertigo.关键词
内淋巴囊手术/梅尼埃病/鼓室内注射/眩晕Key words
endolymphatic sac surgery/Meniere's disease/intratympanic injection/vertigo分类
医药卫生引用本文复制引用
司瑜,卓师培,黄艳,何武辉,邓荆蔓,楼锦涛,张志钢..基于倾向评分匹配分析内淋巴囊手术治疗梅尼埃病的效果[J].中国临床医学,2025,32(2):165-170,6.基金项目
国家自然科学基金(82173154,82471155),广东省自然科学基金(2022A1515012436),中山大学临床研究5010计划(2024004).Supported by National Natural Science Foundation of China(82173154,82471155),Natural Science Foundation of Guangdong Province(2022A1515012436)and Sun Yat-Sen University Clinical Research 5010 Study(2024004). （82173154,82471155）
