中国临床医学2025，Vol.32Issue(2)：171-176,6.DOI:10.12025/j.issn.1008-6358.2025.20250086
椭圆囊功能检测在梅尼埃病不同临床分期中的应用
Application of utricle function testing in different clinical stages of Meniere's disease
摘要
Abstract
Objective To explore the role of ocular vestibular evoked myogenic potential(oVEMP)and unilateral centrifugation subjective visual vertical(UC-SVV)tests in evaluating the utricular function of patients with Meniere's disease(MD)at different clinical stages.Methods A total of 97 unilateral MD patients at Shandong Provincial ENT Hospital from July 2019 to September 2021 were selected.All patients underwent oVEMP,UC-SVV,and pure tone audiometry tests.MD patients were classified into clinical stages 1,2,3,and 4,with stages 1 and 2 defined as early stage and stages 3 and 4 as late stage.The results of utricular function tests(abnormal rates of oVEMP,UC-SVV,and oVEMP+UC-SVV)were compared among patients at different stages.Spearman correlation analysis was used to evaluate the correlation between utricular function and clinical staging.Results Among the 97 MD patients,the abnormal rate of oVEMP was 66.0%(64/97),and the abnormal rate of UC-SVV was 55.7%(54/97).The abnormal rates of oVEMP and oVEMP+UC-SVV in early-stage patients were significantly lower than those in late-stage patients(P＜0.05),while the difference in UC-SVV abnormal rates between the two groups was not statistically significant.Intra-group comparisons showed that the abnormal rate of oVEMP+UC-SVV in stage 1 patients was significantly lower than that in stage 2 patients(P＜0.05),without significant difference in the other indices.There were no significant differences among the three indices in stages 3 and 4 patients.Spearman correlation test results indicated that the abnormal rate of oVEMP(r=0.336,P=0.001)and the abnormal rate of oVEMP+UC-SVV(r=0.301,P=0.003)were weakly positively correlated with clinical staging,while there was no correlation between the abnormal rate of UC-SVV and clinical staging(r=0.022,P=0.832).Conclusions Both oVEMP and UC-SVV tests can assess utricular function in MD patients at different clinical stages.Their combination is helpful of early-stage(stages 1 and 2)MD diagnosis.关键词
梅尼埃病/椭圆囊/临床分期/眼肌前庭诱发肌源性电位/单边离心主观视觉垂直线Key words
Meniere's disease/utricle/clinical staging/ocular vestibular evoked myogenic potential/unilateral centrifugation subjective visual vertical分类
临床医学引用本文复制引用
李远令,李霄飞,宋永栋,吕亚峰,陈月玲,张道宫..椭圆囊功能检测在梅尼埃病不同临床分期中的应用[J].中国临床医学,2025,32(2):171-176,6.基金项目
国家自然科学基金青年项目(82101226,82401364).Supported by Youth Program of National Natural Science Foundation of China(82101226,82401364). （82101226,82401364）
