中国临床医学2025，Vol.32Issue(2)：268-275,8.DOI:10.12025/j.issn.1008-6358.2025.20241189
存在营养风险呼吸系统疾病患者不同启动时间营养干预效果比较
Comparison of nutritional intervention effects at different initiation time in patients with respiratory diseases at nutritional risk
摘要
Abstract
Objective To assess the effect of early nutritional intervention on the patients with respiratory diseases at nutritional risk.Methods A total of 130 patients with respiratory disease who were hospitalized in Shanghai Fifth People's Hospital,Fudan University between May 2023 and December 2024 and had a nutritional risk screening 2002 score≥3 points.Based on the initiation time of nutritional intervention,patients were divided into an early group(≤5 days,n=65)and a late group(＞5 days,n=65).Results In the early group,prealbumin(P-ALB)and retinol-binding protein(RBP)levels were significantly higher(P＜0.01),C-reactive protein(CRP),procalcitonin(PCT)levels were significantly lower after intervention(P＜0.05).Compared with the late group,the hospital costs were lower and hospital stays were shorter in the early group(P＜0.001).Spearman analysis showed ALB,P-ALB,and total protein(TP)were negatively correlated with hospital costs(r=-0.37,-0.20,and-0.22,P＜0.05).RBP,ALB,P-ALB,and lymphocyte count(LYM)were negatively correlated with CRP(r=-0.30,-0.26,-0.37,-0.18,P＜0.01),RBP,ALB,P-ALB,hemoglobin(HB),and TP were negatively correlated with PCT(r=-0.23,-0.36,-0.40,-0.30,-0.19,P＜0.05).Conclusions For patients with respiratory diseases,early nutritional assessment should be underwent,and for patients with nutritional risk screening 2002 score≥3 points,early nutritional intervention could improve the nutritional status and alleviate inflammatory response,promote recovery,shorten the hospital stays.关键词
营养干预/启动时间/呼吸系统疾病/炎症反应/营养状态Key words
nutritional intervention/initiation time/respiratory disease/inflammation response/nutritional status分类
临床医学引用本文复制引用
王利红,崔源,火少晔,赵蕴华,魏玉环,蒋蓉,邵春海..存在营养风险呼吸系统疾病患者不同启动时间营养干预效果比较[J].中国临床医学,2025,32(2):268-275,8.基金项目
2019年复旦大学附属上海市第五人民医院院内科研课题助推项目(2019WYZT01).Supported by Intra-Hospital Research Fund Program of Shanghai Fifth People's Hospital,Fudan University,Shanghai(2019WYZT01). （2019WYZT01）
