中国临床医学2025，Vol.32Issue(2)：288-294,7.DOI:10.12025/j.issn.1008-6358.2025.20250084
穿刺活检针道处理方式对钇-90选择性内放射治疗肝癌的影响
Effect of different liver biopsy needle track management on Yttrium-90 selective internal radiation therapy on liver cancer
徐振远 1刘学 1申淑群 1徐志嘉 1李长凯 1杨业发1
作者信息
- 1. 海军军医大学第三附属医院介入放射科,上海 200438
- 折叠
摘要
Abstract
Objective To explore the effect of different needle track management on Yttrium-90 microsphere selective internal radiation therapy(90Y-SIRT)on liver cancer after liver biopsy.Methods A retrospective analysis was conducted on the clinical data of 21 patients with liver cancer who underwent Technetium-99m-macroaggregated albumin(99mTc-MAA)evaluation and 90Y-SIRT after liver biopsy from June 2023 to December 2024.The methods of needle track management,hepatic arteriovenous shunting,and lung shunt fraction(LSF)were recorded.The occurrence of hepatic arteriovenous fistula(HAVF),as well as the corresponding countermeasures were analyzed.Results Among the 21 liver cancer patients,7 cases(medical glue group)underwent embolization of the needle tract with medical glue(N-butyl 2-cyanoacrylate[NBCA])immediately after biopsy,and no significant HAVF was observed during the 99mTc-MAA tests;14 cases(non-medical glue group)were treated with delayed needle extraction or gelatin sponge particle blocking after biopsy,among which 7 cases developed significant HAVF,and the fistulas were treated with NBCA.The LSF of the medical glue group was significantly lower than that of the non-medical glue group([7.06±2.33]%vs[12.43±7.73]%,P=0.037).All 21 patients successfully completed 90Y-SIRT.Conclusions Liver biopsy may affect 90Y-SIRT by causing iatrogenic HAVF.Immediate NBCA-embolization of the needle tract after biopsy or timely NBCA-embolization of fistulas during 99mTc-MAA tests may reduce the impact.关键词
肝癌/选择性内放射治疗/钇-90/肝活检/动静脉瘘Key words
liver cancer/selective internal radiation therapy/Yttrium-90/liver biopsy/arteriovenous fistula分类
临床医学引用本文复制引用
徐振远,刘学,申淑群,徐志嘉,李长凯,杨业发..穿刺活检针道处理方式对钇-90选择性内放射治疗肝癌的影响[J].中国临床医学,2025,32(2):288-294,7.
