摘要
Abstract
Objective To investigate the clinical efficacy of needle-free water-light injection of hyaluronic acid combined with tranexamic acid in the treatment of melasma.Methods A total of 100 patients with melasma were randomly divided,and the tranexamic acid group(n=50)was given oral tranexamic acid,and the combined group(n=50)was treated with needle-free water light injection of tranexamic acid combined with tranexamic acid,and the clinical efficacy of the two groups was compared.Results The total effective rate of the combined group was 94.00%,which was greatly higher than the 80.00%of the tranexamic acid group(P＜0.05).After treatment,the combined group had lower scores in the melasma area and severity index(MASI)compared to the tranexamic acid group(P＜0.01),the scores of social relations,psychological,environmental,and physiological in the World Health Organization Quality of Life(WHOQOL-BREF)were higher than those in the tranexamic acid group(P＜0.01),the satisfaction level was higher than that in the tranexamic acid group(P＜0.05).After 1 year of follow-up,the recurrence rate of combined group was 4.00%,which was significantly lower than 18.00%in tranexamic acid group(P＜0.05).Conclusion For patients with melasma,the use of needle-free water-light injection of hyaluronic acid combined with tranexamic acid treatment can further improve the therapeutic effect,improve symptoms,improve quality of life,and reduce the recurrence rate,which can provide better treatment options for patients with melasma.关键词
黄褐斑/无针水光注射/透明质酸/氨甲环酸/联合治疗Key words
chloasma/needle-free water-light injection/hyaluronic acid/tranexamic acid/clinical efficacy分类
临床医学
