中国普通外科杂志2025，Vol.34Issue(3)：555-562,8.DOI:10.7659/j.issn.1005-6947.230441
胰腺神经内分泌肿瘤合并肝转移的治疗研究进展
Research progress in the treatment of pancreatic neuroendocrine neoplasms with liver metastases
摘要
Abstract
Pancreatic neuroendocrine neoplasms(pNENs)are rare and highly heterogeneous pancreatic tumors with insidious clinical manifestations.They have a high propensity for distant metastasis,with liver metastases being the most common,significantly impacting patient prognosis.Despite extensive research on treating pNEN with liver metastases in recent years,many controversies and gaps remain.With the advancement of multidisciplinary treatment approaches,therapeutic strategies for pNEN liver metastases have been continuously refined,encompassing surgical resection,local therapies(such as radiofrequency ablation and transarterial interventions),and systemic treatments(including chemotherapy,targeted therapy,immunotherapy,radionuclide therapy,and endocrine therapy).Combination therapy has become an emerging trend.Radical surgery remains the preferred option for resectable cases,while for inoperable or treatment-intolerant patients,a rational combination of local and systemic therapies can improve survival outcomes.Additionally,endocrine therapy is crucial in symptom relief and quality-of-life improvement for patients with functional pNEN.Multidisciplinary collaboration in formulating individualized treatment plans can significantly enhance patient prognosis.This review summarizes recent advancements in treating pNEN liver metastases,providing a reference for clinical decision-making.关键词
胰腺肿瘤/神经内分泌肿瘤/肿瘤转移/肝/综述Key words
Pancreatic Neoplasms/Neuroendocrine Neoplasms/Neoplasm Metastasis/Liver/Review分类
临床医学引用本文复制引用
陆绍龙,王小波,万叶剑,林杰,陈洁..胰腺神经内分泌肿瘤合并肝转移的治疗研究进展[J].中国普通外科杂志,2025,34(3):555-562,8.基金项目
广西科技计划基金资助项目(桂科AB22080066) （桂科AB22080066）
广西自然科学基金资助项目(2024JJB140755). （2024JJB140755）
