中国普通外科杂志2025，Vol.34Issue(3)：563-571,9.DOI:10.7659/j.issn.1005-6947.240649
RhoA/ROCK信号通路在急性胰腺炎中的作用机制研究进展
The role and mechanisms of the RhoA/ROCK signaling pathway in acute pancreatitis:research progress
摘要
Abstract
Acute pancreatitis(AP)is a severe digestive system emergency characterized by high morbidity and mortality,with a complex pathogenesis involving multiple signaling pathways.Among them,the RhoA/ROCK signaling pathway plays a crucial role in the onset and progression of AP,influencing pancreatic inflammation,fibrosis,microcirculatory regulation,and interactions with other signaling pathways.Studies have shown that inhibiting the RhoA/ROCK signaling pathway can effectively alleviate AP severity,reduce inflammatory cytokine levels,and improve pancreatic microcirculation,offering new therapeutic insights and potential strategies for AP treatment.Therefore,this review systematically summarizes the structure and function of the RhoA/ROCK signaling pathway,explores its mechanistic role in AP progression,and further discusses its potential clinical applications.By integrating existing research findings,this paper aims to provide new perspectives on the role of this signaling pathway in AP and offer a theoretical foundation for future basic research and clinical applications.关键词
胰腺炎/RhoA/ROCK通路/微循环/炎症/综述Key words
Pancreatitis/RhoA/ROCK Pathway/Microcirculation/Inflammation/Review分类
临床医学引用本文复制引用
雷寰,夏鑫,林治宇,汪涛..RhoA/ROCK信号通路在急性胰腺炎中的作用机制研究进展[J].中国普通外科杂志,2025,34(3):563-571,9.基金项目
四川省自然科学基金资助项目(41C4137G). （41C4137G）
