中国美容医学2025，Vol.34Issue(5)：126-130,5.
水杨酸凝胶联合多西环素治疗面部中度痤疮疗效分析
Analysis of Efficacy and Clinical Observation of Salicylic Acid Gel Combined with Oral Administration of Doxycycline in the Treatment of Moderate Acne
摘要
Abstract
Objective To explore the efficacy of salicylic acid gel combined with oral administration of doxycycline in the treatment of moderate acne.Methods A total of 60 patients with moderate acne who were treated in department of dermatology of the hospital between June 2023 and September 2023 were selected as the observation subjects.All the selected patients were divided into test group and control group by the random number table method,with 15 cases in each group.The control group was given oral administration of doxycycline tablets,and the test group was treated with salicylic acid gel on the basis of the control group.The counts of skin lesions,clinical curative effect,scores of VISIA skin image analyzer,non-invasive skin physiological function test and the occurrence of adverse reactions were compared between the two groups after treatment.Results After 8 weeks of treatment,the total effective rate of test group was 86.7%,and that of the control group was 60%(P＞0.05).The absolute values of the red zone in both groups were significantly improved compared with those before treatment(P＜0.05).The absolute scores of other zones in the test group were significantly improved compared with those in the control group(P＜0.05).The test group showed better improvement in the water content of the stratum corneum(SCH)and transdermal water loss(TEWL)compared to the control group(P＜0.05).Conclusion Salicylic acid gel combined with oral administration of doxycycline has a certain effect,and can significantly improve skin tone,texture,pores and skin barrier with moderate acne.It has good safety and is worthy of clinical application.关键词
水杨酸/多西环素/中度痤疮/皮肤屏障Key words
salicylic acid/doxycycline/moderate acne/skin barrier分类
医药卫生引用本文复制引用
蒲欣悦,李雪,刘小菡,丁慧静,曲燕..水杨酸凝胶联合多西环素治疗面部中度痤疮疗效分析[J].中国美容医学,2025,34(5):126-130,5.基金项目
2023年烟台市科技创新发展计划政策引导类项目(编号:2023YD052) （编号:2023YD052）
