中国药理学与毒理学杂志2025，Vol.39Issue(4)：303-309,7.DOI:10.3867/j.issn.1000-3002.2025.04.008
血小板衍生的细胞外囊泡在靶向药物递送中的应用进展
Advances in applications of platelet-derived extracellular vesicles in drug target delivery
摘要
Abstract
Extracellular vesicles(EVs)are subcellular components released by cells,which can carry proteins,lipids,mRNA and miRNA,and other biomolecules.They play a significant role in main-taining the intracellular environment and mediating intercellular communication.In recent years,EVs have attracted much attention in the field of drug delivery.Platelet-derived extracellular vesicles(P-EVs)not only possess the advantages of extracellular vesicles but also integrate the unique properties of platelets.P-EVs have unique application value in in vivo drug delivery.This article reviews the extrac-tion methods of P-EVs,their targeting mechanisms and drug loading methods as drug delivery carriers,as well as the research progress in the treatment of various diseases,providing new solutions and ideas for drug application and disease treatment.关键词
血小板/细胞外囊泡/药物递送Key words
patelet/etracellular vesicles/drug delivery分类
医药卫生引用本文复制引用
彭蕴慧,张士坤,季守平..血小板衍生的细胞外囊泡在靶向药物递送中的应用进展[J].中国药理学与毒理学杂志,2025,39(4):303-309,7.基金项目
国家自然科学基金(82204277) National Natural Science Foundation of China(82204277) （82204277）
