中国药理学与毒理学杂志2025，Vol.39Issue(4)：310-320,11.DOI:10.3867/j.issn.1000-3002.2025.04.009
仿生纳米系统在生物毒素解毒中的应用研究进展
Research progress in biomimetic nanosystems for biotoxin detoxification
摘要
Abstract
Biotoxins are natural chemical substances produced by animals,plants or microorgan-isms that exhibit toxicity toward other species.These biotoxins exhibit a wide range of structural complexi-ties.Some of them are highly toxic,posing significant threats to human health and public safety.In recent years,researchers have employed the cell membranes of biotoxin target cells to coat nanomate-rials,thereby constructing biomimetic nanosystems with high biocompatibility,low immunogenicity,prolonged circulation time,and strong targeting capabilities.By leveraging the interactions between biotoxins and their target cell membranes,these systems effectively trap toxins,leading to notable advancements in this field.This article reviews the toxic mechanisms of biotoxins,the historical devel-opment of using biomimetic nanosystems for toxin detoxification,common preparation methods and characterization techniques,as well as the composition and detoxification efficacy of these nanosys-tems,thus providing references for their future design,development,and application.关键词
仿生纳米系统/生物毒素/解毒Key words
biomimetic nanomaterials/biotoxin/detoxification分类
医药卫生引用本文复制引用
淦新悦,宋居星私,邹帅军,王倩倩,张黎明..仿生纳米系统在生物毒素解毒中的应用研究进展[J].中国药理学与毒理学杂志,2025,39(4):310-320,11.基金项目
国家重点研发计划(2019YFC0312605) National Key Research and Development Program(2019YFC0312605) （2019YFC0312605）
