Abstract
[Objective]To detect the expression of glucose transporter 1 associated long chain noncoding ribonucleic acid(LncRNA GAL)in gastric cancer tissue,and explore its relationship with clinical pathological features and survival prognosis.[Methods]A total of 106 gastric cancer patients treated with radical surgery in the 989th Hospital of the PLA Joint Logistic Support Force from January 2019 to October 2020 were selected.The expression of LncRNA GAL in gastric cancer tissue and adjacent normal tissue was detected,and the expression of LncRNA GAL in gastric cancer tissue of patients with different clinical pathological characteristics was compared.All patients with gastric cancer were followed up for 3 years after surgery,and those who survived for 3 years were classified as the survival group,while those who died were classified as the death group.The influencing factors of 3-year postoperative death in gastric cancer patients were analyzed using Cox regression analysis method.The survival rate of patients with different expressions of LncRNA GAL in gastric cancer tissue was analyzed using Kaplan-Meier survival curve.[Results]During a 3-year follow-up period,4 out of 106 gastric cancer patients were excluded,and the remaining 102 gastric cancer patients had a mortality rate of 31.37%(32/102).The relative expression level of LncRNA GAL in gastric cancer tissue was higher than that in adjacent normal tissue(P<0.05).The relative expression levels of LncRNA GAL in gastric cancer tissues of patients with tumor diameter<5 cm,medium to high differentiation,TNM stage I to II,T1 to T2 stage,no lymph node metastasis,and no vascular invasion were lower than those of patients with tumor diameter≥5 cm,low differentiation,TNM stage III,T3 to T4 stage,lymph node metastasis,and vascular invasion,respectively(P<0.05).The proportion of non-intestinal,poorly differentiated,TNM stage III,T3 to T4 stage,lymph node metastasis,vascular invasion,and the relative expression of LncRNA GAL in gastric cancer tissue in the death group were higher than those in the survival group(P<0.05).Low differentiation(R^R=2.910,95%CI:1.333 to 6.349),TNM stage III(R^R=4.063,95%CI:1.933 to 8.540),T3 to T4 stage(R^R=2.675,95%CI:1.247 to 5.734),lymph node metastasis(R^R=2.316,95%CI:1.117 to 4.802),vascular invasion(R^R=3.142,95%CI:1.530 to 6.451),and increased relative expression of LncRNA GAL in gastric cancer tissue(R^R=2.125,95%CI:1.297 to 3.482)were risk factors for postoperative 3-year mortality in gastric cancer patients(P<0.05).Compared with patients with low expression of LncRNA GAL in gastric cancer tissue,the patients with high expression of LncRNA GAL in gastric cancer tissue had a lower 3-year survival rate(P<0.05).[Conclusion]The expression of LncRNA GAL in gastric cancer tissue is elevated,and it is related to tumor diameter,infiltration degree,differentiation degree,clinical stage,lymph node metastasis,and vascular invasion,and it is a factor affecting survival prognosis.关键词
胃癌/临床病理特征/生存预后/长链非编码核糖核酸/葡萄糖转运蛋白1Key words
gastric cancer/clinical pathological features/survival prognosis/long chain noncoding ribonucleic acid/glucose transporter 1分类
临床医学
