中国医学工程2025，Vol.33Issue(4)：43-48,6.DOI:10.19338/j.issn.1672-2019.2025.04.009
MIF与妊娠期糖尿病发病风险的相关性研究
Correlation between MIF and risk of diabetes in pregnancy
摘要
Abstract
[Objective]To analyze the correlation between macrophage migration inhibitory factor(MIF)and the risk of developing gestational diabetes mellitus(GDM).[Methods]This study was a retrospective study,which included 62 GDM patients who visited Maternal and Child Health Hospital of Jiaozuo City from January 2022 to October 2023 as the case group,and 50 healthy volunteers who underwent physical examinations at the hospital during the same period as the control group.The risk factors for GDM were summarized,and the predictive efficacy of MIF on the risk of developing GDM was verified.[Results]The results of statistical univariate analysis showed that in the case group,BMI≥24 kg/m2,family history of diabetes,hypertension,no exercise habits,visceral fat area(VFA)≥10 cm2,the proportion of fasting blood glucose(FBG)≥7.0 mmol/L,2-hour postprandial blood glucose(2hPG)≥11.0 mmol/L,fasting insulin(FINS)>6.1 mmol/L,homeostatic model assessment of insulin resistance(HOMA-IR)>2.69,and MIF protein>30 μg/mL,MIF mRNA>0.5 were higher than those of the control group(χ2=5.397,9.397,4.583,5.358,12.641,13.194,15.574,22.067,22.782,23.748,20.174,P<0.05).The results of logistic multiple regression analysis showed that,BMI≥24 kg/m2,VFA≥10 cm2,FBG≥7.0 mmol/L,2hPG≥11.0 mmol/L,FINS>6.1 mmol/L,HOMA-IR>2.69,MIF protein>30 μg/mL,MIF mRNA>0.5 were risk factors for the onset of GDM(P<0.05).After testing,the FBG,2hPG,FINS,HOMA-IR,MIF protein,MIF mRNA were 9.45±2.36 mmol/L,14.49±3.23 mmol/L,7.45±1.27 mmol/L,3.55±0.26,35.25±8.42 μg/mL,0.77±0.21,higher than those of the control group(5.12±1.45 mmol/L,9.36±1.75 mmol/L,5.33±1.25 mmol/L,2.12±0.31,28.44±5.28 μg/mL,0.38±0.11)(t=11.355,10.094,8.844,26.550,4.981,11.877,P<0.05).Verified by reciever operating characteristic(ROC)curve,the predictive sensitivity of MIF protein level and MIF mRNA relative expression to GDM were 82.49%and 81.72%,respectively,with specificity of 79.43%and 75.36%,and cutoff values of 31.85 μg/mL and 0.58(AUC>0.85).[Conclusion]Obesity,blood glucose disorders,insulin resistance,and elevated MIF are risk factors for the onset of GDM.Monitoring MIF protein and mRNA may enable early prediction of GDM.关键词
妊娠期糖尿病/巨噬细胞移动抑制因子/发病风险/预测效能Key words
gestational diabetes/macrophage migration inhibitory factor/disease risk/predictive performance分类
临床医学引用本文复制引用
王艳利,王哲,张海凤..MIF与妊娠期糖尿病发病风险的相关性研究[J].中国医学工程,2025,33(4):43-48,6.基金项目
河南省医学科技攻关项目(LHGJ2021002231) （LHGJ2021002231）
