中国医学工程2025，Vol.33Issue(4)：58-62,5.DOI:10.19338/j.issn.1672-2019.2025.04.012
艾司氯胺酮对胸腔镜下乳腺癌根治术不良情绪及术后恢复情况的影响研究
Effect of esketamine on adverse emotion and postoperative recovery after thoracoscopic breast cancer radical operation
摘要
Abstract
[Objective]To observe the effect of esketamine on the bad mood and postoperative recovery of patients undergoing thoracoscopic radical breast cancer surgery.[Methods]This study is a prospective study.The subjects were 96 patients who received thoracoscopic radical surgery for breast cancer from October 2022 to December 2023 in the First Affiliated Hospital of Nanyang Medical College.They were divided into general anesthesia group(48 cases)and combined group(48 cases)by computer random grouping method.The general anesthesia group was given regular general anesthesia,and the combined group was assisted by esketamine general anesthesia.The postoperative analgesia and sedation effects,anesthesia recovery,neurotransmitter levels,adverse emotion scores of the two groups were compared.[Results]Under different anesthesia regimens,the Visual Analogue Scale(VAS)scores of the combined group at 1 hour and 3 hours postoperatively were 2.33±0.25 points and 3.25±0.41 points,lower than the general anesthesia group(3.25±0.36 points and 4.12±1.47 points)(t=14.543,3.950;P<0.05).The Ramsay Sedation Scale(RSS)scores were 3.77±0.27 points and 3.25±0.33 points,higher than the general anesthesia group(3.12±0.36 points and 2.78±0.35 points)(t=10.007,6.769;P<0.05).The postoperative eye opening time and post-anesthetic care unit(PACU)stay time of the combined group were 11.17±2.36 min and 15.16±3.29 min,similar to those in the general anesthesia group(10.83±2.41 min and 14.73±3.31 min)(t=0.698,0.638;P>0.05).The postoperative patient-controlled intravenous analgesia(PCIA)pump application time and hospital stay in the combination group were 24.33±5.26 h and 8.45±1.21 d,lower than the general anesthesia group(27.62±5.33 h and 10.29±2.36 d)(t=3.044,4.807;P<0.05).The glutamic acid(GLU)of the combined group at 24 and 48 hours after surgery were 35.33±5.41 U/L and 40.49±5.28 U/L,higher than the general anesthesia group(32.25±5.36 U/L and 37.29±5.33 U/L)(t=2.802,2.955;P<0.05).The norepinephrine(NE)were 55.39±10.22 μg/L and 70.23±10.42 μg/L,higher than the conventional group(50.23±10.46 μg/L and 65.29±10.44 μg/L)(t=2.445,2.320;P<0.05).The Patient Health Questionnaire-9(PHQ-9)and the Generalized Anxiety Disorder-7(GAD-7)scores within 48 hours after surgery in the combined group were 11.25±3.36 points and 13.51±3.18 points,lower than the general anesthesia group(13.26±3.39 points and 15.54±3.75 points)(t=2.918,2.860;P<0.05).[Conclusion]Esketamine assisted general anesthesia can enhance the postoperative analgesic and sedative effects of breast cancer patients undergoing radical surgery,and can lower the level of neurotransmitters and improve the patients'bad mood.关键词
乳腺癌根治术/全身麻醉/艾司氯胺酮/神经递质/不良情绪Key words
radical mastectomy for breast cancer/general anesthesia/esketamine/neurotransmitters/negative emotions分类
临床医学引用本文复制引用
曹鹏,白泉城,张凤君..艾司氯胺酮对胸腔镜下乳腺癌根治术不良情绪及术后恢复情况的影响研究[J].中国医学工程,2025,33(4):58-62,5.基金项目
河南省医学科技攻关项目(LHGJ20210162) （LHGJ20210162）
