摘要
Abstract
[Objective]To observe the therapeutic effect of continuous arterial infusion chemotherapy on advanced oral cancer.[Methods]This study was a prospective study,with 93 patients with advanced oral cancer admitted to Huanghe S&T College Affiliated Hospital from January 2022 to January 2023.The enrolled patients were randomly divided into a conventional group(46 cases)and a perfusion group(47 cases)using computer randomization.The conventional group received surgical treatment and postoperative chemotherapy,while the perfusion group received continuous arterial infusion neoadjuvant chemotherapy in combination with the conventional group.All patients were followed up for one year after treatment,and the short-term efficacy and prognosis of the two groups were compared.[Results]Under different treatment plans,the AFP,TPS and CA199 of the perfusion group were 20.45±5.31 μg/L,50.33±10.29 U/mL,and 32.25±5.36 U/mL,respectively,lower than those in the conventional group(23.49±5.25 μg/L,55.45±10.28 U/mL,35.44±5.28 U/mL)(P<0.05).The ORR and DCR values of the perfusion group were 85.11%(40/47)and 91.49%(43/47),higher than those of the conventional group[65.22%(30/46)and 69.57%(32/46)](P<0.05).The incidence of adverse reactions during treatment in the perfusion group[25.53%(12/47)]was similar to the conventional group[21.74%(10/46)](P>0.05).During the follow-up period,the KPS and QOL scores of the perfusion group were 85.49±10.25 and 85.33±10.27,higher than those of the conventional group(80.32±10.36 and 80.31±10.52),and the ZPS score of the perfusion group(1.36±0.33)was lower than that of the conventional group(1.78±0.85)(P<0.05).As of the end of follow-up,the median PFS and median OS of the perfusion group were 9.33±1.26 months and 10.47±2.25 months,higher than those of the conventional group(8.36±1.41 months and 9.35±1.29 months)(P<0.05).[Conclusion]Continuous arterial infusion of neoadjuvant chemotherapy can improve the short-term efficacy of patients with advanced oral cancer,and effectively improve their short-term prognosis without significantly increasing the risk of chemotherapy side effects.关键词
口腔癌/持续动脉灌注化疗/近期疗效/短期预后Key words
oral cancer/continuous arterial infusion chemotherapy/recent therapeutic effects/short term prognosis分类
医药卫生
