中国医科大学学报2025，Vol.54Issue(4)：318-322,5.DOI:10.12007/j.issn.0258-4646.2025.04.006
术前血糖控制与糖尿病合并宫颈癌患者围手术期胰岛素抵抗的关系及对预后的影响
Relationship between preoperative blood glucose control and perioperative insulin resistance in patients with diabetes mellitus complicated by cervical cancer and its effect on prognosis
摘要
Abstract
Objective To investigate the relationship between preoperative blood glucose control and perioperative insulin resistance(IR)in patients with diabetes mellitus(DM)complicated by cervical cancer(CC)and its effect on prognosis.Methods A total of 100 patients were categorized into IR(n=61)and non-IR(n=39)groups based on their IR levels.Additionally,patients were classified into poor prognosis(n=34)and good prognosis(n=66)groups according to the occurrence of adverse events during the follow-up period.The clini-cal data of each group were compared to evaluate the association of glycosylated hemoglobin(HbA1c),fasting plasma glucose(FPG),and two-hour postprandial plasma glucose(2hPG)with perioperative IR,as well as correlation between HbA1c,FPG,and 2hPG levels and the homeostasis model assessment(HOMA)of IR with the risk of poor prognosis.Results HbA1c,FPG,2hPG,and HOMA-IR were identi-fied as risk factors for the prognosis of patients with DM and CC(P＜0.05).Compared with the respective control groups,the IR group and poor prognosis group had higher preoperative levels of HbA1C,FPG,and 2hPG(P＜0.05).Conclusion Poor preoperative blood glucose control is positively correlated with the risk of perioperative IR in patients with DM and CC.Moreover,HOMA-IR,HbA1c,FPG,and 2hPG are independent risk factors for poor prognosis in patients with DM and CC.关键词
宫颈癌/糖尿病/胰岛素抵抗/预后Key words
cervical cancer/diabetes mellitus/insulin resistance/prognosis引用本文复制引用
邱红兵,任亚男,李晓明,谢震..术前血糖控制与糖尿病合并宫颈癌患者围手术期胰岛素抵抗的关系及对预后的影响[J].中国医科大学学报,2025,54(4):318-322,5.基金项目
国家自然科学基金(81471175) （81471175）
邢台市重点研发计划自筹项目(2022ZC1231) （2022ZC1231）
