中国医科大学学报2025，Vol.54Issue(4)：346-350,358,6.DOI:10.12007/j.issn.0258-4646.2025.04.011
血清vWF、MCP-1、GDF-15联合检测对凶险性前置胎盘患者产后出血的预测价值
Predictive value of combined detection of serum vWF,MCP-1,and GDF-15 for postpartum hemorrhage in patients with pernicious placenta previa
摘要
Abstract
Objective To investigate the predictive value of the combined detection of serum von Willebrand factor(vWF),monocyte chemotactic protein-1(MCP-1),and growth differentiation factor-15(GDF-15)for postpartum hemorrhage in patients with pernicious placenta previa(PPP).Methods One hundred and twelve patients with PPP admitted to our hospital between January 2021 and January 2024 were selected as the study group.They were further divided into a postpartum hemorrhage group and a non-postpartum hemorrhage group and 112 pregnant women with normal placental position during the same period were selected as the control group.ELISA was used to detect serum vWF,MCP-1,and GDF-15 levels.Results Serum vWF,MCP-1,and GDF-15 levels were significantly higher in the study group than in the control group(P＜0.05).Serum vWF,MCP-1,and GDF-15 levels were significantly higher in the postpartum hemorrhage group than in the non-postpartum hemorrhage group(P＜0.05).Logistic regression analysis identified vWF,MCP-1,and GDF-15 levels as factors influencing postpartum hemorrhage for women with PPP(P＜0.05).The combination of serum vWF,MCP-1,and GDF-15 predicted postpartum hemorrhage in women with PPP better than either factor alone(P＜0.05).Conclusion Combined detection of serum vWF,MCP-1,and GDF-15 levels has predictive value for postpartum hemorrhage in women with PPP.关键词
血管性血友病因子/单核细胞趋化蛋白-1/生长分化因子-15/凶险性前置胎盘/产后出血/预测Key words
von Willebrand factor/monocyte chemotactic protein-1/growth differentiation factor-15/pernicious placenta previa/post-partum hemorrhage/prediction分类
医药卫生引用本文复制引用
刘慧强,魏琰平,孟斐,张雯,刘喜翠,丁妮娜..血清vWF、MCP-1、GDF-15联合检测对凶险性前置胎盘患者产后出血的预测价值[J].中国医科大学学报,2025,54(4):346-350,358,6.基金项目
山西省基础研究计划(202203021221277) （202203021221277）
