中国输血杂志2025，Vol.38Issue(4)：474-481,8.DOI:10.13303/j.cjbt.issn.1004-549x.2025.04.003
献血者丙氨酸氨基转移酶筛查检测结果分析与质量管理措施
Analysis of alanine aminotransferase screening results in blood donors and quality management measures
臧亮 1周磊 1常乐 2王露楠2
作者信息
- 1. 大连市血液中心,辽宁 大连 116001
- 2. 北京医院 国家老年医学中心 国家卫生健康委临床检验中心中国医学科学院老年医学研究院,北京 100730
- 折叠
摘要
Abstract
Objective To explore quality issues and quality management measures in alanine aminotransferase(ALT)testing,aiming to improve consistency and accuracy of ALT test results by analyzing the outcomes from different pre-donation screening methods and different sample sources.Methods Data were collected from 58 blood collection and supply institu-tions across China.ALT test results from donor samples analyzed by dry chemistry analyzers,semi-automatic biochemical analyzers,and automatic biochemical analyzers were compared,focusing on the influence of venous versus capillary blood samples on testing accuracy.By comparing results from pre-donation screening with laboratory testing,the current state of quality management for different methods and sample types was assessed.Differences in ALT unqualified rates between labo-ratories were analyzed,and quality improvement strategies were proposed accordingly.Results No significant differences were found in laboratory ALT unqualified rates between venous and capillary blood samples during pre-donation screening across different analytical methods(P>0.05).However,laboratory ALT unqualified rates were consistently lower for ve-nous blood compared to capillary blood,regardless of the testing method used(P<0.05).Notable differences in quality con-trol were observed among various blood collection and supply institutions(P<0.05).Conclusion Minimal differences were observed between pre-donation ALT screening results obtained by the three analytical methods and laboratory test outcomes;thus,blood stations can select an appropriate testing method according to their specific conditions.Pre-donation screening using venous blood samples demonstrated superior reliability in quality control compared to capillary blood samples.Signifi-cant variations in ALT unqualified rates among blood stations suggest that blood collection and supply institutions should em-phasize quality management at both the pre-donation screening and laboratory testing stages.Measures such as optimized standardized operating procedures,regular equipment calibration and maintenance,proficiency testing,internal quality con-trol,inter-system comparisons,and enhanced personnel training and evaluation should be implemented to ensure consistent and stable screening results,thereby reducing ALT unqualified rates.关键词
丙氨酸氨基转移酶/采前筛查/质量管理/献血者Key words
alanine aminotransferase(ALT)/pre-donation screening/quality management/blood donors分类
临床医学引用本文复制引用
臧亮,周磊,常乐,王露楠..献血者丙氨酸氨基转移酶筛查检测结果分析与质量管理措施[J].中国输血杂志,2025,38(4):474-481,8.
