中国输血杂志2025，Vol.38Issue(4)：482-487,6.DOI:10.13303/j.cjbt.issn.1004-549x.2025.04.004
丙氨酸氨基转移酶不合格重复献血者检测情况分析
Analysis of detection of repeat blood donors with unqualified alanine aminotransferase
摘要
Abstract
Objective To retrospectively analyze the detection results of alanine aminotransferase(ALT)unqualified repeat blood donors in Guangzhou,so as to provide evidence for further expanding the repeat blood donor pool,reducing the rate of blood discarding and improving the qualified rate of blood test.Methods Blood donors with unqualified ALT in Guangzhou Blood Center from January 2018 to April 2024 were selected as the research objects.The past blood donation and population characteristics were analyzed according to the number of blood donations and ALT unqualified times.Results Among repeat blood donors with previous ALT disqualification,99.5%to 99.7%did not have reactive markers for transfu-sion-transmitted diseases(TTD),which was higher than the rate among first-time blood donors with unqualified ALT(95.8%)(P<0.05).The rate of single-item ALT disqualification in repeat blood donors was higher in males than in fe-males(P<0.05);it also varied by age(18-25 years>26-35 years>36-45 years>over 45 years)(P<0.05);and by quarter(third and fourth quarters>first and second quarters)(P<0.05).The ALT unqualified rate was significantly high-er whole blood donors than that of platelet donors and returning blood donors(P<0.05).The overall ALT level(51.0 U/L),individual ALT level(56.0 U/L)and individual ALT unqualified rate(66.7%)of repeat blood donors with multiple ALT disqualifications were higher than those of repeat blood donors with single-item ALT disqualifications(26.0 U/L,38.5 U/L,and 33.3%,respectively)(P<0.05).Moreover,as the number of ALT disqualifications increased,the overall level of ALT in repeat blood donors also increased(P<0.05),and the average level of individual ALT and individual ALT unqualified ratio tended to increase.Repeat blood donors with frequent ALT disqualifications had higher ALT levels(69.0 U/L).Conclusion The ALT unqualified rates of repeat blood donors were mostly non-specific elevation without TTD.Re-peat blood donors with multiple ALT disqualifications tend to have continuous high ALT.Moreover,and with the increase of ALT disqualifications times,the overall ALT levels the average individual ALT levels and individual ALT unqualified rates showed an increasing trend.关键词
重复献血者/血液检测/ALTKey words
repeat blood donors/blood detection/alanine aminotransferase(ALT)分类
临床医学引用本文复制引用
曾梓建,梁华钦,王淏,廖芬芳,谢君谋,万芷婷,杜荣松,李仲平,梁浩坚,黎世杰,姬艳丽..丙氨酸氨基转移酶不合格重复献血者检测情况分析[J].中国输血杂志,2025,38(4):482-487,6.基金项目
广州市科技计划项目(2024A03J0447,2025A03J3452) （2024A03J0447,2025A03J3452）
广东省医学科学技术研究基金项目(A2024391) （A2024391）
广州市医学重点学科(2025-2027) （2025-2027）
