中国输血杂志2025，Vol.38Issue(4)：488-494,7.DOI:10.13303/j.cjbt.issn.1004-549x.2025.04.005
深圳地区献血者丙氨酸氨基转移酶检测结果分析及阈值调整策略的探讨
Alanine transferase test results and exploration of threshold adjustment strategies for blood donors in Shenzhen,China
摘要
Abstract
Objective To conduct a retrospective statistical comparison of alanine aminotransferase(ALT)test values in blood donors prior to blood collection,aiming to analyze the objective characteristics of the population with elevated ALT levels(ALT>50 U/L)and provide reference data for adjusting the screening eligibility threshold for ALT.Methods The preliminary ALT screening data of 30 341 blood donor samples collected prior to blood donation from three smart blood dona-tion sites at the Shenzhen Blood Center between 2022 and 2023 were extracted and compared with data from a health exami-nation department of a tertiary hospital in Shenzhen(representing the general population,n=24 906).Both datasets were categorized and statistically described.A retrospective analysis was conducted to examine the associations between ALT test results and factors such as donors' gender,age,ethnicity,donation site,donation season,and frequency of blood donation.Results The ALT levels in both blood donors and the general population were non-normally distributed.The 95th percen-tile of ALT values was calculated as 61.4 U/L(male:67.8 U/L,female:39.3 U/L)for blood donors and 58.1 U/L(male:63.7 U/L,female:51.2 U/L)for the general population.The non-compliance rates(ALT>50 U/L)were 7.65%(2 321/30 341)in blood donors and 7.08%(1 763/24 906)in the general population.There were significant differences(P<0.05)in the ALT failure rate among blood donors based on gender,age,and donation site,but no significant differ-ences(P>0.05)during the blood donation season.There was no statistically significant difference(P>0.05)in the posi-tive rates of four serological markers(HBsAg,anti HCV,HIV Ag/Ab,anti TP)for blood screening pathogens between ALT unqualified and qualified individuals(2.05%vs 1.5%).If the ALT qualification threshold was raised from 50 U/L to 90 U/L,the non qualification rates of male and female blood donors would decrease from 9.82%(2 074/21 125)to 2.23%(471/21 125)and from 2.70%(249/9 216)to 0.75%(69/9 216),respectively.Among the 154 blood donors who do-nated blood more than 3 times,88.31%of the 248 ALT test results were in the range of 50-90 U/L.Among them,9 cases had ALT>130 U/L,and ALT was converted to qualified in subsequent blood donations.Conclusion There are differences in the ALT failure rate among blood donors of different genders and ages,and different blood donation sites and operators can also affect the ALT detection values of blood donors.The vast majority of blood donors with ALT failure are caused by transient and non pathological factors.With the widespread use of blood virus nucleic acid testing,appropriately increasing the ALT qualification threshold for blood donors can expand the qualified population and alleviate the shortage of blood sources,and the risk of blood safety will not increase.关键词
无偿献血者/丙氨酸氨基转移酶/血液筛查/差异对比/分析Key words
voluntary blood donors/alanine aminotransferase(ALT)/blood screening/retrospective statistical analy-sis分类
临床医学引用本文复制引用
郑欣,曾劲峰,薛原野,王皓飚,伍立桃,李然,党英男,陈婷婷,许晓绚,曾雪珍..深圳地区献血者丙氨酸氨基转移酶检测结果分析及阈值调整策略的探讨[J].中国输血杂志,2025,38(4):488-494,7.基金项目
深圳市医疗卫生三名工程(SZSM202311032) （SZSM202311032）
