中国输血杂志2025，Vol.38Issue(4)：495-501,7.DOI:10.13303/j.cjbt.issn.1004-549x.2025.04.006
长春地区献血者丙氨酸氨基转移酶初筛与实验室复检不合格情况分析
Analysis of unqualified ALT results in the initial screening and re-examination of blood donors in Changchun,China
摘要
Abstract
Objective To investigate the non-pathological influencing factors of the unqualified alanine aminotrans-ferase(ALT)in the initial screening of blood donors in Changchun and the laboratory re-examination,so as to provide evi-dence for reducing the deferral of blood donors and the discarding of blood due to ALT disqualification.Methods The un-qualified results of ALT from the laboratory of our center from September 1,2023 to October 31,2024 were collected.The unqualified rates of ALT were statistically analyzed according to the blood collection sites and the initial screening detection equipment.The samples after ALT pre-donation screening were tested in the laborator,and the unqualified rates of ALT in the initial screening and the laboratory,the non-conformity rate of the results and the distribution range of ALT values were statistically analyzed according to the blood collection sites and the initial screening detection equipment.A questionnaire survey was conducted on the blood donors before blood collection to statistically analyze the influence of the blood donors'living habits and diet on ALT test results.Results The statistical analysis of the unqualified rate of ALT in the laboratory showed statistically significant differences in the ALT disqualification rates among different blood collection sites and differ-ent initial screening detection devices(P<0.05).Comparison of the ALT unqualified rate for the same type of equipment at different sites showed that for Equipment 1,there were differences between the combined blood collection house and the whole blood house,and between the combined blood collection house and the blood donation vehicle(P<0.05);for Equip-ment 2,there were differences between the combined blood collection house and the blood donation vehicle,and between the whole blood house and the blood donation vehicle(P<0.05);there were no significant differences among other groups with the same equipment.The initial screening and the laboratory test results for the same samples were compared,with un-qualified rates of ALT of 16.29%and 13.01%,respectively.There were statistically significant differences in the unquali-fied rates of ALT among different blood collection sites(P<0.05),but no significant differences in the ALT test results a-mong different detection equipment(P>0.05)..The non-conformity rate between the initial screening and the laboratory re-sults was 5.26%,of which 81.15%(99/122)were unqualified in the initial screening but qualified in the laboratory.There were statistically significant differences in those unqualified in the initial screening but qualified in the laboratory a-mong different blood collection sites and different detection equipment(P<0.05).The median ALT level in the initial screening was 29.0 U/L(with a 5%-95%range of 14-75 U/L),and the median ALT level in the laboratory was 19 U/L(with a 5%-95%range of 8-65 U/L).The results of the questionnaire survey showed that 33.3%(2/6)of those who consumed alcohol within 24 hours before blood donation had unqualified ALT,and 10%(1/10)of those who stayed up late the night before blood donation had unqualified ALT.Conclusion The unqualified rates of ALT in the initial screening be-fore blood collection and the laboratory re-examination of blood donors in Changchun are closely related to the blood collec-tion sites,detection equipment,detection environment,detection personnel,samples,ALT thresholds and detection time.Drinking alcohol and staying up late within 24 hours before blood donation increase the risk of unqualified ALT detection.关键词
献血者/ALT/不合格率/影响因素Key words
blood donors/ALT/unqualified rate/influencing factors分类
临床医学引用本文复制引用
何敏,崔婧茹,王智勇,马洋..长春地区献血者丙氨酸氨基转移酶初筛与实验室复检不合格情况分析[J].中国输血杂志,2025,38(4):495-501,7.基金项目
吉林省卫生健康科技能力提升计划项目(2024A212) （2024A212）
