中国输血杂志2025，Vol.38Issue(4)：502-507,6.DOI:10.13303/j.cjbt.issn.1004-549x.2025.04.007
青海省藏族自治州献血者丙氨酸氨基转移酶异常原因分析及血液筛查策略的探讨
Analysis of abnormal ALT in blood donors in five Zang autonomous prefectures of Qinghai Province,China:char-acteristics and screening strategies
摘要
Abstract
Objective To investigate the factors associated with alanine aminotransferase(ALT)abnormalities in multi-ethnic blood donors across five Zang autonomous prefectures in the plateau regions of Qinghai Province,and to provide evidence for ensuring blood safety and formulating screening strategies.Methods A retrospective analysis was performed on the ALT abnormal test results of blood donors in the Zang autonomous prefectures of Qinghai from 2022 to 2024.The cor-relations between ALT levels and factors including gender,age,altitude,and infectious markers were investigated.Results The overall ALT unqualified rate among blood donors in this region was 9.01%.Significant differences in ALT levels were observed across genders and age groups(P<0.05).Variations in ALT abnormality rates were also noted among different plat-eau regions(P<0.05).Overall,ALT values exhibited an increasing trend with rising altitude.The average ALT unqualified rates were 11.19%in Zang donors,7.96%in Han donors,and 4.79%in donors from other ethnic groups(P<0.05).No statistically significant association was observed between ALT abnormality and the presence of HBV/HCV infectious markers(P>0.05).Conclusion In the plateau areas of Qinghai,multi-ethnic blood donors have a relatively high ALT levels and ALT unqualified rates,showing distinct regional characteristics.ALT elevation in voluntary blood donors is related to non-pathological factors such as gender,age,and dietary habits,but not to infectious indicators.关键词
高原/多民族/丙氨酸氨基转移酶/血液资源/筛查策略Key words
plateau/multi-ethnic/alanine aminotransferase(ALT)/blood resources/screening strategies分类
医药卫生引用本文复制引用
党英男,李艳霞,叶贤林,曾劲峰,沙娜·哈勒木别克,汤戎,黄立勤,吴海林,陈婷婷,李生菊,孙艳丽,郑欣..青海省藏族自治州献血者丙氨酸氨基转移酶异常原因分析及血液筛查策略的探讨[J].中国输血杂志,2025,38(4):502-507,6.基金项目
中共中央组织部等"西部之光"项目(组通字[2024]17号) （组通字[2024]17号）
中共青海省委组织部"西部之光"项目(青组字2024-180号) （青组字2024-180号）
深圳市"医疗卫生三名工程"项目资助(项目编号SZSM202311032). （项目编号SZSM202311032）
