中药材2024，Vol.47Issue(10)：2499-2504,6.DOI:10.13863/j.issn1001-4454.2024.10.016
草珊瑚中倍半萜类成分的研究
Study on Sesquiterpenoids from Sarcandra glabra
摘要
Abstract
Objective:To study the sesquiterpenoids from Sarcandra glabra.Methods:A combination of silica gel column chroma-tography,Sephadex LH-20 column chromatography and semi-prepared HPLC was used to isolate and purify the sesquiterpenoids from Sarcandra glabra.The structures of the compounds were identified according to the physical and chemical properties and spectral data.Results:Eighteen sesquiterpenoids were isolated from Sarcandra glabra whole herb and identified as 1β-acetoxy-eudesma-4(15),7(11)-dien-8α,12-olide(1),1β-acetoxy-8β-hydroxyeudesman-4(15),7(11)-dien-8,12-olide(2),1-hydroxyeudesma-3,7(11)-dien-8-one(3),1-hydroxyeudesma-4(15),7(11)-dien-8-one(4),germacrone-1,10;4,5-diepoxide(5),norspathulenol(6),9α-hydroxy-atrac-tylenolide Ⅰ(7),neolitacumone C(8),8(9)-en-atractylenolide Ⅰ(9),hydroxyisogermafurenolide(10),9α-hydroxy-5α-H-eudesma-4(15),7(11)-dien-8α,12-olide(11),12-oxochloraniolide A(12),8-epiasterolid(13),atractylenolide Ⅲ(14),atractylenolide Ⅰ(15),neolitacumone B(16),spathulenol(17),chloranthalactone A(18),respectively.Conclusion:Among them,compounds 1 to 6 are isolated from the Chloranthaceae for the first time,and compounds 7 to 13 are isolated from Sarcandra genus for the first time.关键词
草珊瑚/倍半萜/分离鉴定Key words
Sarcandra glabra(Thunb.)Nakai/Sesquiterpenoids/Isolation and identification分类
医药卫生引用本文复制引用
李亚婷,王青,马存根,李石飞..草珊瑚中倍半萜类成分的研究[J].中药材,2024,47(10):2499-2504,6.基金项目
山西省科技厅基础研究计划青年项目(202303021212239) （202303021212239）
山西中医药大学优秀博士毕业生来晋工作奖励经费科研启动基金项目(2023BKS08) （2023BKS08）
山西中医药大学博士科研启动基金项目(2023BK13) （2023BK13）
