中药材2024，Vol.47Issue(11)：2768-2773,6.DOI:10.13863/j.issn1001-4454.2024.11.017
血红天麻新鲜块茎的化学成分及其抗菌活性研究
Chemical Constituents from the Fresh Tuber of Gastrodia elata with Dark Red Pedicel and Their Antibacterial Activities
摘要
Abstract
Objective:To study the chemical constituents and the antibacterial activities of fresh tuber of Gastrodia elata with dark red pedicel.Methods:The chemical components form the ethanol extract of the fresh tuber of Gastrodia elata with dark red pedicel were systematically isolated and purified by various chromatographic separation techniques.The structures of the compounds were analyzed according to its physicochemical properties and spectral data.Results:Sixteen compounds were isolated from fresh tuber of Gastrodia elata with dark red pedicel and identified as p-hydroxybenzaldehyde(1),p-hydroxybenzyl methyl ether(2),4-[[4-(4-hydroxybenzyl)phenoxy]methyl]phenol(3),bis(3,4-dihydroxyphenyl)methane(4),4-(ethoxymethyl)-2-(4-hydroxybenzyl)phenol(5),gastropo-lybenzylol E(6),N6-(4-hydroxybenzyl)adenine riboside(7),obacunone(8),limonin(9),β-sitosterol(10),linoleic acid(11),methyl linoleate(12),ethyl linoleate(13),glyceryl linoleate(14),ethyl linolenate(15),monolinolenin(16),respectively.Conclusion:Among them,compounds 8,9,11 to 16 are isolated from Gastrodia for the first time.The results of in vitro activity study show that compounds 14 and 15 have strong inhibitory effect on Streptococcus paramammary,and compounds 3 and 5 have good antibacterial effect.关键词
血红天麻/酚类化合物/三萜/脂肪酸/抗菌活性Key words
Gastrodia elata Bl.with dark red pedicel/Phenolics/Triterpenoids/Fatty acids/Antibacterial activity分类
医药卫生引用本文复制引用
王大昌,杨洋,黄宁,黄明进,郭刚,沈寿茂..血红天麻新鲜块茎的化学成分及其抗菌活性研究[J].中药材,2024,47(11):2768-2773,6.基金项目
贵州省中药材产业发展项目(黔财农[2019]175号,[2020]101号,[2021]145号) （黔财农[2019]175号,[2020]101号,[2021]145号）
贵州大学'SRT计划'项目资助(2023SRT442) （2023SRT442）
