中西医结合慢性病杂志2025，Vol.2Issue(1)：1-5,5.
强壮灵合剂对小鼠的镇痛、耐缺氧及抗疲劳作用
Analgesic,Anti-hypoxia and Anti-fatigue Effects of Qiangzhuangling Mixture(强壮灵合剂)on Mice
摘要
Abstract
Objective To investigate the analgesic,anti-hypoxia and anti-fatigue effects of Qiangzhuangling Mixture(强壮灵合剂)on mice.Methods The pain threshold of mice to adverse stimulation was determined by acetic acid induced writhing test,hot water tail shrinking test and hot plate test,and the content of cyclooxygenase-2 in mice was determined after acetic acid induced inflammation.The anti-hypoxia effects of Qiangzhuangling Mixture were investigated by normal pressure hypoxia tolerance test,sodium nitrite poisoning test and acute cerebral ischemia hypoxia test;the anti-fatigue effects of Qiangzhuangling Mixture were investigated by weight-bearing swimming test and determination of serum urea nitrogen,blood lactic acid,liver glycogen and muscle glycogen in fatigue mice.Results Compared with the normal control group,the latency of acetic acid-induced writhing was significantly prolonged,the number of writhing was reduced,the latency of tail retraction was significantly prolonged,and the time of licking hind feet was prolonged in the hot plate experiment.After 3 days of acetic acid-induced pain,the content of COX-2 in serum of mice increased significantly,which was inhibited by Qiangzhuangling Mixture.After administration of Qiangzhuangling Mixture,the survival time of mice under normal pressure and hypoxia was prolonged,and the survival time of mice with nitrite poisoning,acute cerebral ischemia and hypoxia was prolonged.Compared with the normal control group,the exhaustive swimming time of mice in the treatment group was prolonged,the content of serum urea nitrogen was decreased,the accumulation of lactic acid in blood was decreased,and the content of liver glycogen and muscle glycogen were increased.Conclusion Qiangzhuangling Mixture has a similar but mild analgesic effect to aspirin,as well as significant anti hypoxia and anti-fatigue effects.关键词
强壮灵合剂/镇痛/耐缺氧/抗疲劳Key words
Qiangzhuangling Mixture(强壮灵合剂)/analgesia/anti-hypoxia/anti-fatigue分类
医药卫生引用本文复制引用
王绍洁,徐志立,张莹,邵慧迪,张栩铭,赵鑫宇,李威..强壮灵合剂对小鼠的镇痛、耐缺氧及抗疲劳作用[J].中西医结合慢性病杂志,2025,2(1):1-5,5.基金项目
大连市妇女儿童医疗中心集团院长基金项目(20024-FEJT-YZ-21) （20024-FEJT-YZ-21）
