中西医结合慢性病杂志2025，Vol.2Issue(1)：11-17,7.
淫羊藿苷对卵巢癌的影响:基于网络药理学和细胞研究的荟萃分析
Effect of Icariin on Ovarian Cancer:A Meta Analysis Based on Network Pharmacology and Cellular Research
曹尚美 1庄园 1王薇 1吴作敏 2王韵旨 2王瑞 2付秀虹1
作者信息
- 1. 漯河市中心医院,河南 漯河 462000||漯河医学高等专科学校第一附属医院,河南 漯河 462000||河南省生育力保护与优生重点实验室,河南 漯河 462000
- 2. 漯河市中心医院,河南 漯河 462000||漯河医学高等专科学校第一附属医院,河南 漯河 462000||河南省中药制剂与加工中医药重点实验室,河南 漯河 462000||河南省中药制剂现代化技术研发与临床应用工程研究中心,河南 漯河 462000
- 折叠
摘要
Abstract
Objective To investigate the effect and possible mechanism of icariin(ICA)on ovarian cancer(OC).Methods Bioinformatics analysis was used to identify ICA targeted genes and OC related signaling pathways through network pharmacology.Cell experiments in PubMed,EMBASE,and Web of Science from June 2001 to June 2023 were retrieved to evaluate the effects of traditional ICA and placebo on OC,and the pathways and genes involved in the article were identified.Perform statistical analysis on the therapeutic targets mentioned in the literature.Results A total of 76 studies were retrieved,of which 8 had data that met the inclusion criteria.Analysis of the 14 successfully validated target genes revealed that they are mainly related to pathways such as cell apoptosis and anti-tumor effects.Conclusion ICA treatment for OC is significantly correlated with cell growth inhibition ability and apoptosis induction ability,and the pathways involved in the therapeutic effect may be related to cell apoptosis and anti-tumor effects.关键词
中医药/抗肿瘤/卵巢癌/网络药理学/淫羊藿苷Key words
traditional Chinese medicine/anti-tumor/ovarian cancer/Network pharmacology/icariin分类
医药卫生引用本文复制引用
曹尚美,庄园,王薇,吴作敏,王韵旨,王瑞,付秀虹..淫羊藿苷对卵巢癌的影响:基于网络药理学和细胞研究的荟萃分析[J].中西医结合慢性病杂志,2025,2(1):11-17,7.
