中西医结合慢性病杂志2025，Vol.2Issue(1)：18-25,8.
阿尔茨海默病神经系统相关共病"异病同证"基因组生物信息学分析
Bioinformatics Analysis of the Genome of Alzheimer's Disease Neurologic-related Co-morbidities"Different Disease with Same Symptome"
摘要
Abstract
Objective To explore the biological basis of different disease with same symptome of neurologically related co-morbidities(epilepsy,sleep deprivation,depression)in Alzheimer's disease(AD)by genomic bioinformatics analysis.Methods The GSE63060,GSE63061,GSE140829,GSE143272,GSE98565 and GSE98793 datasets were downloaded as the study subjects,and the Wayne tool was used to screen the differentiated genes between each disease group and the normal control group,and Cytoscape software was used to screen the core genes by topology analysis,and the core genes were enriched by gene ontology(GO)/kyoto encyclopedia of genes and genomes(KEGG)using the OmicShare platform.Results A total of 33 core genes were screened,and the GO enrichment analysis showed that the core genes were mainly enriched in cellular processes,metabolic processes,bioregulation,bioprocess regulation,stimulus response,signaling,developmental processes,multicellular biological processes,immune system processes,multibiotic processes,reproductive processes,and viral processes,and in cellular constituents,mainly enriched in cellular anatomical entities,protein-containing complexes,and in molecular functions are mainly enriched in binding pathways,structural molecular pathways,catalytic activity,translational regulatory activity,transcriptional regulatory activity,ATP-dependent activity,molecular function regulators,molecular adapter activity,molecular carrier activity,and molecular transducer activity;KEGG enrichment analysis shows that the core genes are mainly enriched in the ribosomes,the AGE-RAGE signaling pathway,T helper cell 17(TH17)cellular differentiation,the JAK-STAT signaling pathway,the HIFG signaling pathway,and the HIFG signaling pathway,and the JAK-STAT signaling pathway.STAT signaling pathway,HIF-1 signaling pathway,PD-L1 expression,and PD-1 checkpoint signaling pathway.Conclusion The use of genome bioinformatics analysis to explore the core genes and signaling pathways of AD neurological disorders can,to a certain extent,reveal the mechanism of AD neurologic-related co-morbidities different disease with same symptome.It is of great significance for the modernization of Chinese medicine and for the elaboration of the scientific meaning of individualized diagnosis and treatment.关键词
阿尔茨海默病/神经系统相关共病/异病同证/基因组学/生物信息学Key words
Alzheimer's disease/neurologic-related co-morbidities/different disease with same symptome/genomics/bioinformatics分类
医药卫生引用本文复制引用
杨雅丽,于畅洋,闵冬雨,刘勇明,梁元钰,程美佳,鞠业涛,袁常斌,何晓明,张力..阿尔茨海默病神经系统相关共病"异病同证"基因组生物信息学分析[J].中西医结合慢性病杂志,2025,2(1):18-25,8.基金项目
国家自然科学基金(82174114) （82174114）
沈阳市科学技术计划公共卫生研发专项(医工结合协同创新研究项目)(22-321-32-14) （医工结合协同创新研究项目）
辽宁中医药大学中医脏象理论及应用教育部重点实验室开放基金项目(zyzx2006) （zyzx2006）
