浙江大学学报（医学版）2025，Vol.54Issue(2)：154-160,7.DOI:10.3724/zdxbyxb-2024-0391
动脉血压升高影响经导管主动脉瓣置换术后生物瓣钙化及衰败机制
Impact of elevated arterial blood pressure on bioprosthetic valve calcification and failure after transcatheter aortic valve replacement
摘要
Abstract
Transcatheter aortic valve replacement(TAVR)has emerged as the standard treatment for severe aortic stenosis,demonstrating comparable efficacy to traditional surgery in low and intermediate-risk patients.However,the bioprosthetic valves utilized in TAVR have a limited lifespan,and bioprosthetic valve failure,including calcification,rupture or infection may develop,leading to poor clinical outcomes.Elevated blood pressure has been identified as a key factor in aortic valve calcification,and its role in bioprosthetic valve failure is gaining increasing attention.Hypertension may accelerate the calcification process and exacerbate valve failure due to increased mechanical stress on the valve,activation of the renin-angiotensin system,and enhanced thrombus formation.Furthermore,elevated blood pressure interacts with prosthesis mismatch and paravalvular leak,jointly affecting valve durability.This review explores the impact of elevated blood pressure on bioprosthetic valve calcification and failure after TAVR,and emphasizes the importance of blood pressure control,optimized preoperative assessment,and appropriate valve selection in reducing valve failures.关键词
生物瓣钙化/生物瓣衰败/经导管主动脉瓣置换术/动脉血压升高/综述Key words
Bioprosthetic valves calcification/Bioprosthetic valve failure/Trans-catheter aortic valve replacement/High artery blood pressure/Review分类
医药卫生引用本文复制引用
绳文静,朱齐丰,戴晗怡,周道,刘先宝..动脉血压升高影响经导管主动脉瓣置换术后生物瓣钙化及衰败机制[J].浙江大学学报（医学版）,2025,54(2):154-160,7.基金项目
浙江省自然科学基金(LQ22H020008) （LQ22H020008）
国家重点研发计划(2020YFC2008100) （2020YFC2008100）
浙江大学滨江研究院自研项目(ZY202205SMKY001) （ZY202205SMKY001）
浙江省"尖兵""领雁"研发攻关计划(2022C03063)The study was supported by the Natural Science Foundation of Zhejiang Province(LQ22H020008),National Key R&D Program of China(2020YFC2008100),Independent Research Project of Binjiang Institute of Zhejiang University(ZY202205SMKY001),"Pioneer"and"Leading Goose"R&D Program of Zhejiang Province(2022C03063) （2022C03063）
