中药材2024，Vol.47Issue(5)：1165-1168,4.DOI:10.13863/j.issn1001-4454.2024.05.016
商陆果发酵液化学成分的分离与鉴定
Isolation and Identification of Chemical Constituents in the Fermentation Liquor of the Fruits of Phytolacca acinosa
摘要
Abstract
Objective:To study the chemical constituents of the fermentation liquor of the fruits of Phytolacca acinosa.Methods:The compounds from the 70%methanol extract of the fermentation liquor of Phytolacca acinosa fruits were isolated and purified by col-umn chromatography and semi-preparative HPLC,the structures were identified by means of NMR,MS and other spectral techniques.Results:Thirteen compounds were isolated from the n-butanol faction of 70%methand extract of the fermentation liquor of the fruits of Phytolacca acinosa and identified as(1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid(1),2-methyl-2,3,4,9-tetra-hydro-1H-pyrido[2,3-b]indole(2),methyl leucinate(3),benzeneethanamine(4),4-(2-aminoethyl)phenol(5),2-hydroxyl esculentic acid(6),allantoin(7),methyl succinate(8),methyl-3,4,5-trihydroxycyclohexanecarboxylate(9),ethyl-β-D-xylose(10),(2R)-(4-hydroxyphenyl)lactic acid(11),2(S)-3'-hydroxybutan-2'-2-hydroxypropanoate(13),respectively.Conclusion:Except for compound 6,the other compounds are isolated from Phytolacca genus for the first time and may be secondary metabolites produced during fermen-tation.关键词
商陆果发酵液/化学成分/分离/结构鉴定Key words
Fermentation liquor of the fruits of Phytolacca acinosa Roxb./Chemical constituents/Isolation/Structural identifica-tion分类
医药卫生引用本文复制引用
李彪,孙延平,张文森,苏发智,刘萌,王秋红,匡海学..商陆果发酵液化学成分的分离与鉴定[J].中药材,2024,47(5):1165-1168,4.基金项目
国家中医药管理局中医药传承与创新"百千万"人才工程-岐黄工程首席科学家支持项目(国中医药人教函[2021]7号) （国中医药人教函[2021]7号）
国家中医药管理局中医药传承与创新"百千万"人才工程(岐黄工程)岐黄学者支持项目(国中医药人教函[2018]284号) （岐黄工程）
黑龙江省"头雁"团队支持项目(黑龙江省头雁行动领导小组文件[2019]5号) （黑龙江省头雁行动领导小组文件[2019]5号）
