中国渔业质量与标准2024，Vol.14Issue(6)：38-48,11.DOI:10.3969/j.issn.2095-1833.2024.06.005
水体地西泮暴露对草鱼肌肉中地西泮及其代谢物残留的影响及膳食摄入风险评估
Effects of diazepam in water on residues of diazepam and its metabolites in grass carp muscle and assessment of consumption related health risks
摘要
Abstract
Diazepam,a widely used benzodiazepine tranquilizer for treating conditions such as anxiety,insomnia,and epilepsy,poses significant risks of adverse effects like irritability,headaches,fatigue,and drug dependence upon prolonged exposure.Though not approved for use in aquaculture,its presence has been frequently detected in fresh-water fish species,including grass carp,crucian carp,and common carp.Research on diazepam contamination in ed-ible aquatic products remains sparse,particularly in large-scale farmed fish like grass carp,with limited studies ad-dressing bioaccumulation,metabolic residue patterns,and health risk assessments.Our study conducted a detailed a-nalysis of the accumulation and metabolism of diazepam and its metabolites in grass carp muscle tissue.Our findings indicate that at environmentally relevant concentrations,residues may exceed permissible levels when waterborne dia-zepam concentrations reach 100 ng/L or higher.Among the metabolites,nordazepam was found to be the most abun-dant in grass carp muscle,exhibiting a similar accumulation profile to diazepam with a comparable half-life,high-lighting potential health risks.Additionally,we calculated withdrawal periods using the WT1.4 software under condi-tions where diazepam residues exceed permissible levels.Dietary intake risk assessments,based on residual levels in edible muscle tissues across various exposure concentrations and combined with recommended daily dietary intakes,suggest that diazepam residues in grass carp pose acceptable dietary risks for adults,children,and toddlers.These in-sights are valuable for pollution control,toxicological research,and risk assessment related to diazepam.[Chinese Fishery Quality and Standards,2024,14(6):38-48]关键词
草鱼/地西泮及其代谢物/富集代谢/药代动力学分析/休药期/风险评估Key words
Grass carp/diazepam and its metabolitesBioaccumulation and elimination/pharmacokinetic analysis/withdrawal period/risk assessment分类
农业科技引用本文复制引用
徐小栋,杨臻,李英,贾芳慧,乔璐,胡鑫,徐锦华,孙慧武,穆迎春..水体地西泮暴露对草鱼肌肉中地西泮及其代谢物残留的影响及膳食摄入风险评估[J].中国渔业质量与标准,2024,14(6):38-48,11.基金项目
中国农产品质量安全风险评估项目(GJFP20230401) （GJFP20230401）
中国水产科学研究院中央公益科学机构基础研究基金项目(CAFS2023A002) （CAFS2023A002）
