中国中西医结合杂志2025，Vol.45Issue(4)：422-428,7.DOI:10.7661/j.cjim.20250222.092
药线引流法治疗肉芽肿性小叶性乳腺炎脓肿期气虚毒盛证随机对照研究
Treatment of Granulomatous Lobular Mastitis Patients with Qi Deficiency Toxic Stagnation Syndrome in the Abscess Stage Using the Medication Thread Drainage Method:A Randomized Controlled Trial
摘要
Abstract
Objective To observe the clinical efficacy of medication thread drainage method in treating granulomatous lobular mastitis(GLM)patients with qi deficiency toxic stagnation syndrome(QDTSS)in the abscess stage.Methods Totally 74 patients who met GLM were screened from 108 GLM patients.They were assigned to the experimental group(37 cases)and the control group(37 cases)by randomization digit table.On the basis of routine treatment,patients in the experimental group were treated with medication thread drainage method,while those in the control group were treated with rubber strip drainage method.All patients were treated for 14 successive days.The total effective rates,breast abscess rupture states,the breast lump size and abscess cavity size,the breast lump hardness scores,the skin temperature and color scores of breast abscess area,the Visual Analogue Scale(VAS),C-reactive protein(CRP),percentages of white blood cells(WBC),neutrophilic granulocyte(NE),lymphocyte,Chinese medicine(CM)syndrome scores,and the immunological levels of complement(C)3,C4,immunoglobulin(Ig)G,IgA,and IgM after treatment were compared.Results Three cases dropped out in each group.Finally 34 cases in each group completed this study.The total effective rate of the experimental group was 97.06％(33/34)and the rate of breast abscess rupture was 2.94％(1/34),while the total effective rate of the control group was 35.29％(12/34)and the rate of breast abscess rupture was 23.53％(8/34).The total effective rate of the experimental group was significantly higher than that of the control group(x2=32.013,P＜0.01)and the rate of breast abscess rupture was lower than that of the control group(Fisher's exact test,P＜0.05).Compared with baseline,the breast lump size and the breast abscess cavity size of the patients in the experimental group were reduced after treatment,the breast lump hardness score,the skin color and temperature scores of breast abscess area,the VAS,CRP,WBC count,the percentage of NE,CM syndrome score,IgG C3 and C4 levels of the patients in the experimental group decreased(P＜0.05,P＜0.01).The skin temperature score of breast abscess area,the VAS and CM syndrome scores of the patients in the control group decreased(P＜0.05,P＜0.01).Compared with the control group after treatment,the breast lump size and the breast abscess cavity size were reduced,the breast lump hardness score,the skin color and temperature scores of breast abscess area,the VAS,CRP,the lymphocyte count,WBC count,the percentage ofNE,CM syndrome score,IgG,C3 and C4 levels of the patients in the experimental group decreased(P＜0.01,P＜0.05).Conclusion The medication thread drainage method attenuated inflammatory symptoms of GLM patients with QDTSS in the abscess stage,decreased abnormally elevated blood inflammation and immunological indices,improved CM syndrome,and elevated the total effective rate.(China Clinical Trial Registration Center,No.CHiCTR2200058338)关键词
肉芽肿性小叶性乳腺炎/脓肿期/气虚毒盛证/药线引流法/免疫球蛋白/补体/随机对照试验Key words
granulomatous lobular mastitis/abscess stage/qi deficiency toxic stagnation syndrome/medication thread drainage method/immunoglobin/complement/randomized clinical study引用本文复制引用
李志鲲,程旭锋,刘琦,张文可..药线引流法治疗肉芽肿性小叶性乳腺炎脓肿期气虚毒盛证随机对照研究[J].中国中西医结合杂志,2025,45(4):422-428,7.基金项目
2022年度河南省卫生健康委国家中医临床研究基地科研专项(No.2022JDZX086) （No.2022JDZX086）
河南省中医药重点学科建设项目(No.豫卫中医药科教[2024]1号) （No.豫卫中医药科教[2024]1号）
国家中医药管理局全国名老中医药专家传承工作室建设项目(No.国中医药人教函[2019]41号) （No.国中医药人教函[2019]41号）
