阿尔茨海默病及相关病2025，Vol.8Issue(3)：164-169,193,7.DOI:10.3969/j.issn.2096-5516.2025.03.002
基于中国深圳老龄化相关疾病队列的肝脏纤维化指标与认知功能减退相关性研究
Association of the liver fibrosis markers with cognitive decline in the Shenzhen aging-related disorder cohort in China
摘要
Abstract
Objective:We aimed to explore the association of liver fibrosis markers with cognitive decline.Methods:In this cross-sectional study,there were 8669 participants over 60 years old from 51 Community Health Centers in the Luohu District of Shenzhen from 2017 to 2018.All participants were divided into a cognitive low-risk group(n=8202)and a cognitive high-risk group(n=467)according to their scores of mini-mental state examination and education status.Blood routine examination and liver function markers were tested from fasting blood samples.The liver fibrosis markers FIB-4 and APRI were calculated with parameters such as ALT,AST,and PLT using specific formulas.We used the t-test,Mann-Whitney test,and Chi-square test to analyze the differences in general statistical characteristics and live fibrosis markers between the two groups,and binary Logistic regression analysis was used to analyze each parameter.The association between the liver fibrosis markers and alcohol drinking habits was tested by Spearman rank correlation.Results:FIB-4 was significantly higher in the cognitive high-risk group than the cognitive low-risk group[1.40(1.13,1.78)vs.1.49(1.21,1.88),Z=3.595,P＜0.001]but FIB-4 was not an independent risk factor of cognitive decline[OR(95%CI):0.718(0.444～1.159),P=0.175].For alcohol drinkers,FIB-4 was significantly positively correlated with the age of starting drinking(rs=0.089,P=0.005)and frequency of drinking(rs=0.149,P＜0.001).There was a positive correlation between APRI and frequency of drinking(rs=0.078,P=0.013)as well.For people abstaining from alcohol,FIB-4 exhibited a positive correlation with the age of abstinence(rs=0.172,P=0.014).Conclusion:FIB-4 was elevated in people with cognitive decline,and increased frequency of drinking was correlated with raised FIB-4 and APRI,and giving up drinking as soon as possible might be beneficial to prevent the cognitive decline by liver health.关键词
认知功能减退/肝脏纤维化指标/FIB-4/APRI/肝功能标志物Key words
Cognitive decline/Liver fibrosis marker/FIB-4/APRI/Liver function marker分类
临床医学引用本文复制引用
王昊,刘建军,刘佩意,刘亢丁,朱飞奇,吴凯钰,邱国真,陈淳淳,黎明坤,郭启雯,许春燕,王敏,刘威..基于中国深圳老龄化相关疾病队列的肝脏纤维化指标与认知功能减退相关性研究[J].阿尔茨海默病及相关病,2025,8(3):164-169,193,7.基金项目
深圳市医疗卫生三名工程项目"瑞典卡罗琳斯卡医学院NVS系Bengt Winblad教授阿尔茨海默病团队"(SZSM201801014) （SZSM201801014）
深圳市科创委重点项目"AD前期及患者健康管理大数据构建及其预测预警模型研究"(JCYJ20200109143431341). （JCYJ20200109143431341）
