阿尔茨海默病及相关病2025，Vol.8Issue(3)：188-193,6.DOI:10.3969/j.issn.2096-5516.2025.03.006
胶质-淋巴系统在Aβ清除中作用的研究进展
Advances in the application of the glymphatic system for amyloid-beta clearanc
摘要
Abstract
Alzheimer's disease(AD)is the most common neurodegenerative disease worldwide and a leading cause of dementia.Currently,there are no highly effective treatments for this condition.The imbalance between the production and clearance of Aβ(amyloid-beta)protein is considered a primary pathogenic mechanism of AD.Enhancing the clearance of Aβ in the brain during the early stages can delay the onset and progression of AD.In recent years,with the introduction of the concept of the glymphatic system and the discovery of meningeal lymphatic vessels,the directional transport of fluids within the central nervous system has become a research hotspot.The glymphatic system plays a crucial role in clearing amyloid-beta protein and holds promise as a novel approach to combat neurodegenerative diseases.This review aims to summarize the current research progress on the role of the brain's glymphatic system in AD treatment and explore its potential applications in disease management.关键词
阿尔茨海默病/Aβ/胶质-淋巴系统/神经变性疾病/衰老Key words
Alzheimer's disease/Amyloid-beta/Glymphatic system/Neurodegenerative diseases/Aging分类
临床医学引用本文复制引用
励佳熠,吕中月,吴昊,陈晓,付帆,杨凯霞,谢国民..胶质-淋巴系统在Aβ清除中作用的研究进展[J].阿尔茨海默病及相关病,2025,8(3):188-193,6.基金项目
宁波市医疗卫生品牌学科(Grant No.PPXK2024-01) （Grant No.PPXK2024-01）
浙江省临床重点专科建设项目-神经内科(2023SZZ-2) （2023SZZ-2）
