阿尔茨海默病及相关病2025，Vol.8Issue(3)：194-199,6.DOI:10.3969/j.issn.2096-5516.2025.03.007
脑膜淋巴管与阿尔茨海默病关系的研究进展
Research progress on the relationship between meningeal lymphatic vessels and Alzheimer's disease
摘要
Abstract
The meningeal lymphatic vessels(mLVs)play a crucial role in the complex circulation and exchange of soluble contents between the cerebrospinal fluid(CSF)and the interstitial fluid(ISF).It has been confirmed that mLVs can drain intracranial CSF and immune cells to extracranial deep cervical lymph nodes(dCLNs),thereby establishing a direct link between the central nervous system(CNS)and the peripheral immune system.Given the limited therapeutic options for Alzheimer's disease(AD),enhancing brain lymphatic flow to improve the clearance of toxic waste has emerged as a new approach to alleviating cognitive impairment.This article briefly introduces the discovery process,structure,and location of mLVs,and thoroughly discusses their physiological functions.It focuses on the relationship between mLVs and the pathogenesis of AD,aiming to provide reference for emerging therapeutic mechanisms of AD.关键词
阿尔茨海默病/脑膜淋巴管/中枢神经系统Key words
Alzheimer's disease/Meningeal lymphatic vessels/Central nervous system分类
临床医学引用本文复制引用
崔亚芳..脑膜淋巴管与阿尔茨海默病关系的研究进展[J].阿尔茨海默病及相关病,2025,8(3):194-199,6.基金项目
Mini-CEX联合虚拟仿真教学平台在妇产科临床技能教学培训中的初探和应用 （）
