北华大学学报（自然科学版）2025，Vol.26Issue(3)：329-334,6.DOI:10.11713/j.issn.1009-4822.2025.03.008
淫羊藿治疗心肌损伤的网络药理学分析
Network Pharmacology Analysis of Epimedium brevicornu for Treatment of Myocardial Damage
摘要
Abstract
Objective To analyze the potential active components and corresponding targets of Epimedium brevi-cornu for treating myocardial damage using network pharmacology methods,and to explore its potential mecha-nisms for improving this condition.Methods The TCMSP database was used to screen for the active components of Epimedium brevicornu and predict their corresponding targets.Targets related to myocardial damage were re-trieved from OMIM,TTD and GeneCards databases.The intersections of active components targets and myocardial damage targets were used to create crosstarget Venn diagrams.The STRING platform was employed to establish a protein-protein interaction(PPI)network,while the DAVID database was utilized for GO functional analysis and KEGG pathway enrichment analysis of the targets of Epimedium brevicornu in the context of myocardial damage.Fi-nally,the drug-active conponents-targets-disease network was constructed using Cytoscape 3.9.1 software.Re-sults Through the screening of two parameters-oral bioavailability(OB)and drug-like(DL)properties were obtained 23 active components and 222 corresponding targets.The active components mainly included quercetin,luteolin,sitosterol and kaempferol,among others.By screening the OMIM,TTD and GeneCards databases,we identified 5 608 targets related to myocardial damage.Venn analysis revealed that Epimedium brevicornu and myocardial damage jointly acted on 176 common targets,with core targets including AKT1,IL-6,TNF,TP53 and IL-1β.The PPI network indicates that Epimedium brevicornu and myocardial damage have 176 nodes and 3 705 edges among their common targets.The GO function analysis showed that Epimedium brevicornu mainly exerts its therapeutic effect on myocardial damage through responses to xenobiotic stimuli,positive regulation of gene expression,hypoxia response and other biological processes.It also affected cellular components such as the nucleus,nuclear membrane and extracellular space,as well as molecular functions like enzyme binding and protein-binding nuclear receptor activity.The KEGG pathway enrichment analysis indicated that the pathways were primarily enriched in the cancer,lipid metabolism,atherosclerosis and the PI3K-AKT signaling pathway,among others.Conclusion The therapeutic effects of Epimedium brevicornu in the treatment of myocardial damage are primarily exerted through multiple components,multiple targets and multiple pathways.关键词
网络药理学/淫羊藿/心肌损伤Key words
network pharmacology/Epimedium brevicornu/myocardial damage分类
医药卫生引用本文复制引用
刘腾达,马欣原,崔云鹤,李亭昱,杨朔,郭笑,母润红..淫羊藿治疗心肌损伤的网络药理学分析[J].北华大学学报（自然科学版）,2025,26(3):329-334,6.基金项目
吉林省科技发展计划项目(YDZJ202401432ZYTS) （YDZJ202401432ZYTS）
北华大学研究生创新计划项目(2023067). （2023067）
